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The aim of this article is to review the most relevant information published on the relative contribution of genetic and environmental factors. Large meta\u2010analyses confirmed the association between IL<\/jats:styled-content>8<\/jats:italic>, IL<\/jats:styled-content>10<\/jats:italic>, TNF<\/jats:styled-content>\u2010b<\/jats:italic>, TP<\/jats:styled-content>53<\/jats:italic> and PSCA<\/jats:styled-content><\/jats:italic>, while genetic variation at different genes such as XPG<\/jats:styled-content><\/jats:italic>, PLCE<\/jats:styled-content>1<\/jats:italic>, HFE<\/jats:styled-content><\/jats:italic>, ERCC<\/jats:styled-content>5<\/jats:italic>, EZH<\/jats:styled-content>2<\/jats:italic>, DOC<\/jats:styled-content>2<\/jats:italic>, CYP<\/jats:styled-content>19A1<\/jats:italic>, ALDH<\/jats:styled-content>2<\/jats:italic>, and CDH<\/jats:styled-content>1<\/jats:italic> have been reported to be associated with GC<\/jats:styled-content> risk. Several microRNA<\/jats:styled-content>s have also been associated with GC<\/jats:styled-content> and their prognosis. Cohort studies have shown the association between GC<\/jats:styled-content> and fruit, flavonoid, total antioxidant capacity, and green tea intake. Obesity was associated with cardia GC<\/jats:styled-content>, heme iron intake from meat with GC<\/jats:styled-content> risk. Several large meta\u2010analyses have confirmed the positive association of GC<\/jats:styled-content> with salt intake and pickled foods and the negative association with aspirin use.<\/jats:p>","DOI":"10.1111\/hel.12082","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T06:09:12Z","timestamp":1378706952000},"page":"34-38","source":"Crossref","is-referenced-by-count":89,"title":["Gastric Cancer: Epidemiologic Aspects"],"prefix":"10.1111","volume":"18","author":[{"given":"Carlos A.","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Unit of Nutrition, Environment and Cancer Catalan Institute of Oncology\u2010 Idibell Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00faria","family":"Sala","sequence":"additional","affiliation":[{"name":"Unit of Nutrition, Environment and Cancer Catalan Institute of Oncology\u2010 Idibell Barcelona Spain"},{"name":"Molecular Epidemiology Group, Translational Research 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