{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:14:14Z","timestamp":1696396454884},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T00:00:00Z","timestamp":1391990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> resistance to antibiotics is steadily increasing and multidrug\u2010resistant strains are common and difficult to eliminate, mainly in countries where bismuth, tetracycline, furazolidone, and rifabutin are unavailable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy and safety of a triple therapy with proton\u2010pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>), amoxicillin, and doxycycline in patients with multidrug\u2010resistant <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This prospective study involved 16 patients (13 females; mean age \u2013 50\u00a0\u00b1\u00a011.3\u00a0years) infected by <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> with known resistance to clarithromycin, metronidazole, and levofloxacin, but susceptibility to amoxicillin and tetracycline. All patients were previously submitted to upper endoscopy with gastric biopsies for <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> culture and susceptibility testing by Etest. Mutations in 23S r<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and gyrA genes were determined by real\u2010time PCR. A 10\u2010day eradication regimen with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> (double\u2010standard dose b.i.d.), amoxicillin (1000\u00a0mg b.i.d.), and doxycycline (100\u00a0mg b.i.d.) was prescribed after pretreatment with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> during 3\u00a0days. Eradication success was assessed by <jats:sup>13<\/jats:sup>C\u2010urea breath test 6\u201310\u00a0weeks after treatment. Compliance and adverse events were determined through phone contact immediately after treatment and specific written questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only one patient did not complete treatment due to adverse events. Another four patients experienced mild side effects not affecting compliance. The control <jats:sup>13<\/jats:sup>C\u2010urea breath test was positive in all patients. Per\u2010protocol and intention\u2010to\u2010treat eradication rates were 0%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although safe, a triple\u2010therapy protocol with high\u2010dose <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>, amoxicillin, and doxycycline is useless for multidrug\u2010resistant <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12106","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T08:56:37Z","timestamp":1392022597000},"page":"90-97","source":"Crossref","is-referenced-by-count":17,"title":["Triple Therapy with High\u2010Dose Proton\u2010Pump Inhibitor, Amoxicillin, and Doxycycline Is Useless for <i><scp>H<\/scp>elicobacter pylori<\/i> Eradication: A Proof\u2010of\u2010Concept 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