{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T10:30:14Z","timestamp":1750156214880},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T00:00:00Z","timestamp":1391731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Functional dyspepsia is thought to be a diagnosis made after excluding endoscopically detectable lesions by the current Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria. However, whether these \u201cfunctional dyspepsia\u201d patients were diagnosed appropriately is still controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 223 patients diagnosed with functional dyspepsia by Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria were enrolled. All patients were submitted to endoscopic examination, rapid urease test, and histologic evaluation. We also appraised the effect of a 7\u2010day treatment based on the Glasgow Dyspepsia Severity Score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> infection and neutrophil infiltration were found in 37.7% and 36.3% cases, respectively, and were both more frequent in the subgroup with epigastric pain symptom (<jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) than in the other two subgroups. In addition, neutrophil infiltration was more common and severe in the <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive individuals than in the patients without infection (Mann\u2013Whitney <jats:italic>U\u2010<\/jats:italic>test\u00a0=\u00a0431.500, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The treatment was useful in symptom improvement of all three subgroups, and the <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content> subgroup had the greatest change of symptom scores before and after treatment as compared with the subgroup with postprandial distress symptom (<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content> subgroup (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a042.745, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and the eradication of <jats:italic>H.\u00a0pylori<\/jats:italic> revealed a statistical significant difference in different subgroups (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a011.300, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings showed that many <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive subjects diagnosed as \u201cfunctional dyspepsia\u201d were actually chronic gastritis patients, especially the <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content> cases who are more likely to be patients with \u201cactive gastritis under microscope,\u201d and also benefit most from the treatment of proton\u2010pump inhibitors or eradication of <jats:italic>H.\u00a0pylori<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12108","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T07:57:27Z","timestamp":1391759847000},"page":"124-128","source":"Crossref","is-referenced-by-count":8,"title":["Rome <scp>III<\/scp> Criteria Cannot Distinguish Patients with Chronic Gastritis from Those Functional Dyspepsia Patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Zhu","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Ying","sequence":"additional","affiliation":[{"name":"Center for ADR monitoring of Guangdong Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Mengnan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Yali","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.66"},{"key":"e_1_2_6_4_1","first-page":"773","article-title":"Chronic gastritis and Helicobacter pylori: a histopathological study of gastric mucosal biopsies","volume":"20","author":"Yakoob MY","year":"2010","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.4.366"},{"issue":"4","key":"e_1_2_6_6_1","first-page":"iv33","article-title":"Helicobacter pylori and functional dyspepsia: review of previous studies and commentary on new data","volume":"50","author":"Bazzoli 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