{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:21:06Z","timestamp":1762521666089},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The need for new effective <jats:italic>Helicobacter pylori<\/jats:italic> eradication therapy has focused efforts on the development and optimization of regimens with excellent eradication rates such as 14\u2010day hybrid therapy. This study evaluated whether the duration of hybrid therapy could be reduced while maintaining a high eradication rate and to examine the effect of antibiotic resistance on outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Three separate multicenter pilot studies were carried out concurrently. To reduce selection bias, eligible subjects were randomized to 10\u2010day, 12\u2010day, or 14\u2010day hybrid therapy consisting of esomeprazole 40 mg and amoxicillin 1 gm twice daily for 10, 12, or 14 days plus clarithromycin 500 mg, and metronidazole 500 mg twice daily for the final 7 days. The primary outcome was <jats:italic>H.\u00a0pylori<\/jats:italic> eradication per\u2010protocol assessed at least 8\u00a0weeks after therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 220 subjects were entered. The per\u2010protocol analyses contained 60, 61, 61 subjects in the 10\u2010, 12\u2010 and 14\u2010day therapy studies, respectively. The eradication rates, per\u2010protocol, were similar: 95% (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>); 89.5\u2013100%) for 10\u2010day, 95.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>; 89.7\u2013100%) for 12\u2010day, and 93.4% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>; 87.2\u201399.7%) for 14\u2010day hybrid therapies. Antibiotic resistance was infrequent; however, all metronidazole or clarithromycin resistances were cured with 12\u2010 and 14\u2010day therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that in regions of moderate to low clarithromycin and\/or metronidazole resistance it may be feasible to shorten hybrid therapy to 10 or 12\u00a0days. Further study is needed to compare hybrid and concomitant therapy in regions with moderate\u2010to\u2010high clarithromycin and\/or metronidazole resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12113","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T10:25:00Z","timestamp":1394533500000},"page":"207-213","source":"Crossref","is-referenced-by-count":27,"title":["Feasibility of Shortening 14\u2010day Hybrid Therapy While Maintaining an Excellent <i>Helicobacter pylori<\/i> Eradication Rate"],"prefix":"10.1111","volume":"19","author":[{"given":"Jeng\u2010Yih","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Division of Internal Medicine Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping\u2010I","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Veterans General Hospital National Yang\u2010Ming University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deng\u2010Chyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Division of Internal Medicine Kaohsiung Municipal Hsiao\u2010Kang Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Y.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Medicine Michael E. DeBakey VA Medical Center Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Division of Internal Medicine Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302254"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192757"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61579-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.555"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.210"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/MCG.0b013e3181c8a1a3","article-title":"Sequential therapy for Helicobacter pylori eradication: a critical review","volume":"44","author":"Gisbert JP","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01924.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60825-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.05.028"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00828.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04944.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.07.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05024.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d40"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.7.2169-2178.2003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.8.2133-2142.2000"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612003399059"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005350050092"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.03.050"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2014.859522"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12062"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:16:28Z","timestamp":1696331788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,11]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/hel.12113"],"URL":"https:\/\/doi.org\/10.1111\/hel.12113","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,11]]}}}