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Stomach represents a barrier for microorganism colonization, particularly because of its high hydrochloric acid concentration. The main mechanism developed by <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> to maintain intracellular p<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content> homeostasis in this environment is the urease activity. However, urease negative strains can be also isolated from clinical samples, suggesting that <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> presents other components involved in acid resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Here, we present some evidence that the arginine decarboxylase gene (<jats:italic>spe<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><\/jats:italic>) in <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> could be involved in an acid adaptation mechanism similar to the one in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nterobacteriaceae, which is dependent on the presence of arginine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Indeed, <jats:italic>spe<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><\/jats:italic> m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and protein expression are acutely induced by acid stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Moreover, we showed that <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> uses arginine in an acid response mechanism required for its growth in acid conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Altogether, these results provide novel information regarding the <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> physiology and acid response mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12115","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T04:55:13Z","timestamp":1395032113000},"page":"182-193","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of the Arginine Decarboxylase Gene (<scp>ORF HP<\/scp>0422, <i>speA<\/i>) Involved in Acid Tolerance in <i><scp>H<\/scp>elicobacter pylori<\/i>"],"prefix":"10.1111","volume":"19","author":[{"given":"Manuel","family":"Valenzuela","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Molecular and Cellular Biology Laboratory of Molecular Microbiology ICBM University of Chile Santiago Chile"},{"name":"Toxicology and Cancer Biology Research Group Louvain Drug Research Institute Universit\u00e9 Catholique de Louvain Bruxelles Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u00edbal","family":"C\u00e1ceres","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Molecular and Cellular Biology Laboratory of Molecular Microbiology ICBM University of Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Almarza","sequence":"additional","affiliation":[{"name":"Faculty of Medicine 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