{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:59:35Z","timestamp":1781618375888,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The long\u2010term effect of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> eradication in preventing metachronous gastric cancer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>) development after endoscopic resection (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>) of early gastric cancer (<jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content>) remains controversial. The aim of this study was to investigate the effect of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> status on the incidence of metachronous <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> during long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We retrospectively reviewed the medical records of 374 patients who underwent <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content>. <jats:italic>Helicobacter pylori<\/jats:italic> status was assessed by histology, rapid urease test, and serology. According to the <jats:italic>H.\u00a0pylori<\/jats:italic> status after <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>, included patients were classified into <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010negative group (n\u00a0=\u00a0218), <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010eradicated group (n\u00a0=\u00a049), and <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010persistent group (n\u00a0=\u00a0107). Metachronous <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> incidence and risk factors according to <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> status were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up duration after <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> was 4.3\u00a0years (range 1.0\u201311.3\u00a0years). During the follow\u2010up period, metachronous <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> had developed in 13 patients (6.0% [13\/218]) in the <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010negative group, 2 patients (4.1% [2\/49]) in the <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010eradicated group, and 16 patients (15.0% [16\/107]) in the <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010persistent group. Cumulative incidence of metachronous <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> was significantly higher in patients with <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010persistent group than in those with <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010negative (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.011, log\u2010rank test) and <jats:italic>H.\u00a0pylori\u2010<\/jats:italic>eradicated group (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.006, log\u2010rank test). In a multivariate <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox proportional hazard model, age \u226565\u00a0years (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>] 2.29, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.038), family history of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.60, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.014), and <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori\u2010<\/jats:italic>persistent status (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.42, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.019) were associated with metachronous <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Persistent <jats:italic>H.\u00a0pylori<\/jats:italic> infection after <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> may increase risk of metachronous <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12116","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T09:16:39Z","timestamp":1394442999000},"page":"194-201","source":"Crossref","is-referenced-by-count":44,"title":["The Association Between <i>Helicobacter pylori<\/i> Status and Incidence of Metachronous Gastric Cancer After Endoscopic Resection of Early Gastric Cancer"],"prefix":"10.1111","volume":"19","author":[{"given":"Young\u2010Il","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Ju","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong\u2010Cherl","family":"Kook","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Jeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Yeul","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Gyoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Won","family":"Ryu","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.165381"},{"key":"e_1_2_6_3_1","first-page":"453","article-title":"Endoscopic mucosal resection and endoscopic submucosal dissection in esophageal and gastric cancers","volume":"26","author":"Wang KK","year":"2010","journal-title":"Curr Opin 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