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As our group had successfully isolated special licorice extracts (s\u2010lico) lowering troublesome glycyrrhizin, but increasing licochalcone A, we have compared anti\u2010inflammatory, antioxidative, and cytoprotective actions of s\u2010lico and c\u2010lico against either in vitro or in vivo H<\/jats:styled-content>elicobacter pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec>Methods<\/jats:title>RT<\/jats:styled-content>\u2010PCR<\/jats:styled-content> and W<\/jats:styled-content>estern blot were performed to check anti\u2010inflammatory action and electron spin resonance (ESR<\/jats:styled-content>) and DCFDA<\/jats:styled-content> spectroscopy to check antioxidative action. s\u2010lico or c\u2010lico was pretreated 1\u00a0hours before H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection on AGS<\/jats:styled-content> cells. Interleukin\u201010 deficient mice inoculated H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> and followed with high salt containing pallet diets to produce H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010associated chronic atrophic gastritis and gastric tumors, during which s\u2010lico or c\u2010lico\u2010containing pellet diets were administered up to 24\u00a0weeks.<\/jats:p><\/jats:sec>Results<\/jats:title>s\u2010lico had fabulous efficacy on scavenging ROS<\/jats:styled-content> which was further confirmed by DCFDA<\/jats:styled-content> study and ESR<\/jats:styled-content> measurement. The expressions of COX<\/jats:styled-content>\u20102, iNOS<\/jats:styled-content>, VEGF<\/jats:styled-content>, and IL<\/jats:styled-content>\u20108 were increased after H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection, of which levels were significantly decreased with s\u2010lico in a dose\u2010dependent manner. s\u2010lico significantly ameliorated hypoxia\u2010induced or H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010induced angiogenic activities. s\u2010lico significantly ameliorated H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010induced gastric damages as well as gastritis. Our animal model showed significant development of gastric tumors including adenoma and dysplasia relevant to H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection, and s\u2010lico administration significantly attenuated incidence of H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010induced gastric tumorigenesis.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Special licorice extracts can be anticipating substance afforded significant attenuation of either H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010induced gastritis or tumorigenesis based on potent antioxidative, anti\u2010inflammatory, and antimutagenic actions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12121","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T06:28:10Z","timestamp":1395296890000},"page":"221-236","source":"Crossref","is-referenced-by-count":39,"title":["Special Licorice Extracts Containing Lowered Glycyrrhizin and Enhanced Licochalcone A Prevented 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