{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:16:02Z","timestamp":1771035362576,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Insufficient acid inhibition during <jats:italic>Helicobacter pylori<\/jats:italic> eradication treatment and bacterial resistance to antibiotics often causes eradication failure. Four times daily dosing (q.i.d.) of a proton\u2010pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) achieves potent acid inhibition, suggesting its potential usefulness as a regimen for eradicating <jats:italic>H.\u00a0pylori<\/jats:italic> infection. Therefore, a tailored eradication regimen based on antibiotic susceptibility and maintenance of acid inhibition should have a high success rate. We investigated the efficacy of such treatment based on clarithromycin (<jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>) susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using 153 <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive Japanese patients, we investigated the efficacy of tailored eradication strategy: (1) Patients infected with <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>\u2010sensitive <jats:italic>H.\u00a0pylori<\/jats:italic> were treated with a <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> (rabeprazole 10\u00a0mg q.i.d.), amoxicillin 500\u00a0mg q.i.d., and <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> 200\u00a0mg b.i.d. (n\u00a0=\u00a089), and (2) patients infected with <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>\u2010resistant were given the same doses of rabeprazole and amoxicillin and metronidazole 250\u00a0mg b.i.d. (n\u00a0=\u00a064) for 1\u00a0week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the tailored regimen group, the overall eradication rate was 96.7% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 92.5\u201398.9%, 148\/153) in the intention\u2010to\u2010treat (<jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content>) analysis and 97.4% (93.4\u201399.3%, 148\/152) in the <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> analysis. The eradication rates for the <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>\u2010 and metronidazole\u2010based treatments were similar (95.5% and 98.4%, respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.400). The tailored treatment achieved a high eradication rate in <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19 rapid metabolizers who were a resistance genotype for <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> treatment (94.3% (86.0\u201398.4%, 66\/70)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>A tailored <jats:italic>H.\u00a0pylori<\/jats:italic> eradication regimen based on <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> susceptibility and maintaining acid secretion (rabeprazole 10\u00a0mg q.i.d.) is useful because it can achieve an eradication rate exceeding 95%, irrespective of eradication history, thus overcoming differences among <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19 genotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12128","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T11:37:36Z","timestamp":1396352256000},"page":"312-318","source":"Crossref","is-referenced-by-count":49,"title":["Efficacy of Tailored <i>Helicobacter pylori<\/i> Eradication Treatment Based on Clarithromycin Susceptibility and Maintenance of Acid Secretion"],"prefix":"10.1111","volume":"19","author":[{"given":"Mitsushige","family":"Sugimoto","sequence":"first","affiliation":[{"name":"First Department of Medicine Hamamatsu University School of Medicine Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Uotani","sequence":"additional","affiliation":[{"name":"First Department of Medicine Hamamatsu University School of Medicine Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Sahara","sequence":"additional","affiliation":[{"name":"First Department of 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