{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:27:28Z","timestamp":1782253648516,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lymphocytic gastritis (<jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content>), characterized by marked intra\u2010epithelial lymphocytosis in the gastric mucosa, has been frequently associated with both celiac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) and <jats:italic>H.\u00a0pylori<\/jats:italic> gastritis. The aim of this study was to review and correlate the morphology of <jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content> with the presence of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and <jats:italic>H. pylori<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Gastric biopsies diagnosed with <jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content> from 1\/1\/2006 to 8\/1\/2013 at our institution and corresponding small bowel biopsies, when available, were reviewed for verification of the diagnosis and to assess for the presence of <jats:italic>H. pylori<\/jats:italic> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. Immunohistochemical (<jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>) staining for <jats:italic>H. pylori<\/jats:italic> was performed on all gastric biopsies. Demographic, clinical, and laboratory data were obtained from the medical record.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four of the 56 cases that met inclusion criteria demonstrated significant intra\u2010epithelial lymphocytosis as the predominant histologic abnormality; however, none were associated with <jats:italic>H. pylori<\/jats:italic> infection by <jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content> staining. Two cases that also showed a prominent intra\u2010epithelial and lamina propria neutrophilic infiltrate were both positive for <jats:italic>H. pylori<\/jats:italic> and were excluded from further study. Of the 36 small bowel biopsies available, 19 (53%) showed changes in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content> is not a distinct clinicopathologic entity, but a morphologic pattern of gastric injury that can be secondary to a variety of underlying etiologies. When restricted to cases with lymphocytosis alone, <jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content> is strongly associated with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and not with active <jats:italic>H. pylori<\/jats:italic> infection. However, cases that also show significant neutrophilic infiltrate should be regarded as \u201cactive chronic gastritis\u201d and are often associated with <jats:italic>H. pylori<\/jats:italic> infection. A morphologic diagnosis of <jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content> should prompt clinical and serologic workup to exclude underlying <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12139","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T02:47:13Z","timestamp":1400122033000},"page":"349-355","source":"Crossref","is-referenced-by-count":16,"title":["Lymphocytic Gastritis is not Associated with active <i><scp>H<\/scp>elicobacter pylori<\/i> Infection"],"prefix":"10.1111","volume":"19","author":[{"given":"Jennifer A.","family":"Nielsen","sequence":"first","affiliation":[{"name":"Research Division ProPath 1355 River Bend Dr, Dallas TX 75247 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Gastrointestinal Pathology Division ProPath 1355 River Bend Dr Dallas TX 75247 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna J.","family":"Lager","sequence":"additional","affiliation":[{"name":"Gastrointestinal Pathology Division ProPath 1355 River Bend Dr Dallas TX 75247 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh V.","family":"Putcha","sequence":"additional","affiliation":[{"name":"Texas Digestive Disease Consultants 505 S Nolen Drive Suite B, Southlake TX 76092 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Jain","sequence":"additional","affiliation":[{"name":"Texas Digestive Disease Consultants 505 S Nolen Drive Suite B, Southlake TX 76092 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lewin","sequence":"additional","affiliation":[{"name":"Gastrointestinal Pathology Division ProPath 1355 River Bend Dr Dallas TX 75247 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2008.00478.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70254-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.4.471"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199607000-00010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.9.1258"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711540204"},{"key":"e_1_2_7_8_1","first-page":"81","volume-title":"Gastrointestinal and Liver Pathology: A Volume in the Series Foundations in Diagnostic Pathology","author":"Iacobuzio\u2010Donahue C","year":"2005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2350\/10-05-0833-OA.1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199902000-00003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181b5073a"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.43"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199804000-00010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.12.1111"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.3.282"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.4.495"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02778.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00621.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199402000-00005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/81838"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e51067"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65343-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2000.17871"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.5.436"},{"issue":"2","key":"e_1_2_7_26_1","first-page":"159","article-title":"Lymphocytic gastritis: a distinct nosologic entity or a histopathologic expression of other conditions?","volume":"26","author":"Pezhouh MH","year":"2013","journal-title":"Mod Pathol"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318254f413"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12139","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:47:06Z","timestamp":1696312026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/hel.12139"],"URL":"https:\/\/doi.org\/10.1111\/hel.12139","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}