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For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 deficiency, the diagnosis of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> may possibly play a role. Interestingly, a potential role has also been described for <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> neoplastic diseases, including colorectal and pancreatic cancer. Different mechanisms of action have been proposed, ranging from the induction of a low grade inflammatory state to the occurrence of molecular mimicry mechanisms. 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