{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:06:54Z","timestamp":1765609614313},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Major New Drugs Innovation and Development","award":["No: 2011ZX09302-007-03"],"award-info":[{"award-number":["No: 2011ZX09302-007-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To assess the efficacy and safety of hybrid therapy compared to other pre\u2010existing therapies and to new therapies.<\/jats:p><\/jats:sec>Methods<\/jats:title>Through a search of PubMed, EMBASE<\/jats:styled-content>, the Cochrane Central Register of Controlled Trials, and Conference Proceedings Citation Index, two independent reviewers systemically identified randomized, controlled trials that compared hybrid therapy to other pre\u2010existing and new therapies. Dichotomous data were pooled to obtain the relative risk (RR<\/jats:styled-content>) of the eradication rate, with 95% confidence intervals (CI<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Results<\/jats:title>We identified 6 studies, 5 of which compared hybrid therapy and sequential therapy, and 3 of which compared hybrid therapy and concomitant therapy. Pooled estimates of the 5 randomized controlled trials (RCT<\/jats:styled-content>s) revealed no significant differences between hybrid therapy and sequential therapy and no evidence of heterogeneity (I<\/jats:italic>2<\/jats:sup>\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0%; p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.803), the pooled RR<\/jats:styled-content>s were 1.02 (95% CI<\/jats:styled-content>: 0.93\u20131.12) (intention\u2010to\u2010treat (ITT<\/jats:styled-content>)), and 1.03 (95% CI<\/jats:styled-content>: 0.94\u20131.13) (per protocol (PP<\/jats:styled-content>)). Pooled estimates of the 3 RCT<\/jats:styled-content>s showed no significant differences between hybrid therapy and concomitant therapy with no evidence of heterogeneity (I<\/jats:italic>2<\/jats:sup>\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0%; p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.967), the pooled RR<\/jats:styled-content>s were 0.99 (95% CI<\/jats:styled-content>: 0.89\u20131.10) (ITT<\/jats:styled-content>) and 0.99 (95% CI<\/jats:styled-content>: 0.89\u20131.10) (PP<\/jats:styled-content>). No significant differences in adverse events were noted among hybrid therapy, sequential therapy, and concomitant therapy ((RR<\/jats:styled-content>: 1.13; 95% CI<\/jats:styled-content>: 0.87\u20131.48; I<\/jats:italic>2<\/jats:sup>\u00a0<\/jats:italic>=\u00a0<\/jats:italic>13.2%; p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.327), (RR<\/jats:styled-content>: 0.89; 95% CI<\/jats:styled-content>: 0.73\u20131.08; I<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00%; p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.978) (ITT<\/jats:styled-content>), respectively). After consideration of all treatment arms, the ITT<\/jats:styled-content> eradication rates with hybrid therapy, concomitant therapy, and sequential therapy were 88.6, 86.3, and 84.7%, respectively. And the PP<\/jats:styled-content> eradication rates were 92.1, 92.5, and 87.5%. No significant differences were observed between the groups in terms of compliance.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>All three of these therapies yielded good eradication rates. Hybrid therapy could be an alternative to sequential therapy and concomitant therapy, but additional RCT<\/jats:styled-content>s are needed to confirm this finding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12180","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T06:48:07Z","timestamp":1415429287000},"page":"79-88","source":"Crossref","is-referenced-by-count":32,"title":["Review: Efficacy and Safety of Hybrid Therapy for Helicobacter pylori<\/i> Infection: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Ben","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang 330000 Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You\u2010Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang 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