{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:33:46Z","timestamp":1788870826096,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo de Investigaci\u00c3\u00b3n Sanitaria ISCIII","award":["PI13\/01710"],"award-info":[{"award-number":["PI13\/01710"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The aim of this study was to determine the appropriateness of the recent recommendations for managing\n Helicobacter pylori<\/jats:italic>\n infection in children in a university hospital in Southern Europe. Antimicrobial resistance and response to eradication therapy were also determined.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n The presence of\n H.\u00a0pylori<\/jats:italic>\n was studied in 143 children: by gastric biopsy culture (\n GBC<\/jats:styled-content>\n ),\n 13<\/jats:sup>\n C\u2010urea breath test (\n UBT<\/jats:styled-content>\n ) and stool antigen immunochromatography test (\n SAIT<\/jats:styled-content>\n ) in 56 children; by\n GBC<\/jats:styled-content>\n and\n UBT<\/jats:styled-content>\n in 20, by\n GBC<\/jats:styled-content>\n and\n SAIT<\/jats:styled-content>\n in 18, and by\n GBC<\/jats:styled-content>\n alone in 49. Antimicrobial susceptibility was determined by E\u2010test. Infection was defined as a positive culture or positivity in both\n UBT<\/jats:styled-content>\n and\n SAIT<\/jats:styled-content>\n . Disease progression was studied in 118 patients. First evaluation of symptoms was carried out at 3\u20136\u00a0months after diagnosis and\/or after treatment of the infection.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n H.\u00a0pylori<\/jats:italic>\n was detected in 74 from the 143 children analyzed (100%\n GBC<\/jats:styled-content>\n positive, 98.1%\n UBT<\/jats:styled-content>\n positive, and 58.1%\n SAIT<\/jats:styled-content>\n positive). The main symptom was chronic abdominal pain (n\u00a0=\u00a0121). Macroscopic antral nodularity was observed in 29.7% of infected patients and in 5.8% of uninfected patients, respectively. Resistance to clarithromycin and metronidazole was found in 34.7 and 16.7%, respectively. Eradication when susceptible antimicrobials were used occurred in 78.7% (48\/61) versus 37.5% (3\/8) when the treatment included a drug with resistance (\n p<\/jats:italic>\n \u00a0=\u00a0.024). In patients with recurrent abdominal pain, symptoms resolved in 92.9% (39\/42) patients with\n HP<\/jats:styled-content>\n eradication versus 42.9% (6\/14) without\n HP<\/jats:styled-content>\n eradication (\n p<\/jats:italic>\n \u00a0<\u00a0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Treated patients often failed to meet the criteria established in the guidelines for\n H.\u00a0pylori<\/jats:italic>\n diagnostic screening and treatment because most of them had only recurrent abdominal pain, but remission of their symptoms was associated with\n H.\u00a0pylori<\/jats:italic>\n eradication.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.12187","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T01:44:17Z","timestamp":1415411057000},"page":"169-175","source":"Crossref","is-referenced-by-count":25,"title":["Helicobacter pylori<\/i>\n Infection in Children. Antimicrobial Resistance and Treatment Response"],"prefix":"10.1111","volume":"20","author":[{"given":"Milagrosa","family":"Montes","sequence":"first","affiliation":[{"name":"Servicio de Microbiolog\u00eda\u2010IIS Biodonostia Hospital Universitario Donostia San Sebasti\u00e1n Spain"},{"name":"Biomedical Research Centre Network for Respiratory Diseases (CIBERES) San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor N.","family":"Villalon","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda Infantil Hospital Universitario Donostia San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Eizaguirre","sequence":"additional","affiliation":[{"name":"Servicio de Pediatr\u00eda Hospital Universitario Donostia San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maider","family":"Delgado","sequence":"additional","affiliation":[{"name":"Servicio de Pediatr\u00eda Hospital Universitario Donostia San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio M.","family":"Mu\u00f1oz\u2010Seca","sequence":"additional","affiliation":[{"name":"Servicio de Pediatr\u00eda Hospital Universitario Donostia San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Fern\u00e1ndez\u2010Reyes","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda\u2010IIS Biodonostia Hospital Universitario Donostia San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"P\u00e9rez\u2010Trallero","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda\u2010IIS Biodonostia Hospital Universitario Donostia San Sebasti\u00e1n Spain"},{"name":"Biomedical Research Centre Network for Respiratory Diseases (CIBERES) San Sebasti\u00e1n Spain"},{"name":"Department of Preventive Medicine and Public Health Faculty of Medicine Basque Country University (UPV\/EHU) San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12071"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007480625665"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.61"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00766.x"},{"key":"e_1_2_6_6_1","first-page":"2557","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious","author":"Blaser 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