{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:23:58Z","timestamp":1740126238406,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,15]],"date-time":"2015-02-15T00:00:00Z","timestamp":1423958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1002947"],"award-info":[{"award-number":["GNT1002947"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> pathogenesis results from the inflammation induced by chronic infection. <jats:styled-content style=\"fixed-case\">CBA<\/jats:styled-content> mice are nonresponsive to gastric <jats:italic>Helicobacter<\/jats:italic> infection, providing a useful model for examining host regulation of <jats:italic>Helicobacter<\/jats:italic>\u2010induced gastritis. We examined whether gastric <jats:italic>Helicobacter<\/jats:italic> nonresponsiveness impacts upon vaccine efficacy and whether immune\u2010mediated protection could occur in the absence of inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mice were vaccinated prior to challenge with <jats:italic>Helicobacter felis<\/jats:italic> or <jats:italic>H.\u00a0pylori<\/jats:italic>. Gastritis and <jats:italic>H.\u00a0felis<\/jats:italic> colonization was evaluated histologically. <jats:italic>H.\u00a0pylori<\/jats:italic> colonization was quantified by colony\u2010forming assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunizations protected <jats:styled-content style=\"fixed-case\">CBA<\/jats:styled-content> mice against challenge with either <jats:italic>H.\u00a0felis<\/jats:italic> or <jats:italic>H.\u00a0pylori<\/jats:italic>. Protection against <jats:italic>H.\u00a0felis<\/jats:italic> was marked by a loss of nonresponsiveness and development of an atrophic gastritis with mucus metaplasia. However, vaccine\u2010induced protection against <jats:italic>H.\u00a0pylori<\/jats:italic> was only associated with cell infiltration into the gastric mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nonresponsiveness to gastric <jats:italic>Helicobacter<\/jats:italic> infection did not interfere with vaccination\u2010induced protection. Vaccine\u2010induced protective immunity against <jats:italic>H.\u00a0pylori<\/jats:italic> was linked with the induction of cellular infiltration, but importantly not atrophic gastritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12197","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T01:13:22Z","timestamp":1424049202000},"page":"217-222","source":"Crossref","is-referenced-by-count":3,"title":["Host Nonresponsiveness Does not Interfere With Vaccine\u2010Mediated Protection Against Gastric <i>Helicobacter<\/i> Infection"],"prefix":"10.1111","volume":"20","author":[{"given":"Stacey N.","family":"Harbour","sequence":"first","affiliation":[{"name":"Centre for Animal Biotechnology School of Veterinary Science University of Melbourne Parkville Vic. 3010 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazel M.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney NSW 2052 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Sutton","sequence":"additional","affiliation":[{"name":"Centre for Animal Biotechnology School of Veterinary Science University of Melbourne Parkville Vic. 3010 Australia"},{"name":"Mucosal Immunology Murdoch Childrens Research Institute Royal Children's Hospital Parkville VIC. 3052 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.4.777"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_4_1","first-page":"2111","article-title":"Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach","volume":"55","author":"Blaser 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