{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:05:45Z","timestamp":1791216345311,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:italic>Helicobacter heilmannii<\/jats:italic> sensu lato (<jats:italic>H.\u00a0heilmannii<\/jats:italic> s.l.) group consists of long, spiral\u2010shaped bacteria naturally colonizing the stomach of animals. Moreover, bacteria belonging to this group have been observed in 0.2\u20136% of human gastric biopsy specimens, and associations have been made with the development of chronic gastritis, peptic ulceration, and gastric <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>To gain insight into the prevalence of <jats:italic>H.\u00a0heilmannii<\/jats:italic> s.l. infections in patients suffering from gastric disease in China, <jats:italic>H.\u00a0heilmannii<\/jats:italic> s.l. species\u2010specific <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>s were performed on <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> extracts from rapid urease test (<jats:styled-content style=\"fixed-case\">RUT<\/jats:styled-content>)\u2010positive gastric biopsies from 1517 patients followed by nucleotide sequencing. At the same time, <jats:italic>Helicobacter pylori<\/jats:italic> cultivation and specific <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> was performed to assess <jats:italic>H.\u00a0pylori<\/jats:italic> infection in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, <jats:italic>H.\u00a0heilmannii<\/jats:italic> s.l. infection was detected in 11.87% (178\/1499) of <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive patients. The prevalence of <jats:italic>H.\u00a0suis<\/jats:italic>,<jats:italic> H.\u00a0felis<\/jats:italic>,<jats:italic> H.\u00a0bizzozeronii<\/jats:italic>,<jats:italic> H.\u00a0heilmannii<\/jats:italic> sensu stricto (s.s.), and <jats:italic>H.\u00a0salomonis<\/jats:italic> in the patients was 6.94%, 2.20%, 0.13%, 0.07%, and 2.54%, respectively. Results revealed that all patients with <jats:italic>H.\u00a0heilmannii<\/jats:italic> s.l. infection were co\u2010infected with <jats:italic>H.\u00a0pylori<\/jats:italic>, and some patients were co\u2010infected with more than two different <jats:italic>Helicobacter<\/jats:italic> species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Helicobacter heilmannii<\/jats:italic> s.l. infections are fairly common in Chinese patients. This should be kept in mind when diagnosing the cause of gastric pathologies in patients. <jats:italic>Helicobacter suis<\/jats:italic> was shown to be by far the most prevalent <jats:italic>H.\u00a0heilmannii<\/jats:italic> s.l.species.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12201","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T10:20:06Z","timestamp":1418725206000},"page":"284-290","source":"Crossref","is-referenced-by-count":51,"title":["Prevalence of Coinfection with Gastric Non\u2010<i>Helicobacter pylori Helicobacter<\/i> (<scp>NHPH<\/scp>) Species in <i>Helicobacter pylori<\/i>\u2010infected Patients Suffering from Gastric Disease in Beijing, China"],"prefix":"10.1111","volume":"20","author":[{"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and 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