{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:22:55Z","timestamp":1762521775128},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>) eradication has always been a concern. In our pervious study, 14\u2010day hybrid regimen showed ideal results. Based on these findings, we decided to compare the efficacy of 10\u2010 and 14\u2010day hybrid regimens for <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and seventy patients with peptic ulcer disease and <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection were enrolled in the study. One hundred and thirty\u2010four patients received 10\u2010day hybrid regimen (<jats:styled-content style=\"fixed-case\">PACT<\/jats:styled-content>\u201010): pantoprazole, 40\u00a0mg, and amoxicillin, 1\u00a0g, both twice daily for 10\u00a0days; plus clarithromycin, 500\u00a0mg, and tinidazole, 500\u00a0mg, both twice daily just during the last 5\u00a0days. One hundred and thirty\u2010six patients received 14\u2010day hybrid regimen (<jats:styled-content style=\"fixed-case\">PACT<\/jats:styled-content>\u201014): pantoprazole, 40\u00a0mg, and amoxicillin, 1\u00a0g, both twice a day for 14\u00a0days; plus clarithromycin, 500\u00a0mg, and tinidazole, 500\u00a0mg, both twice daily just for the last 7\u00a0days. Eight weeks after treatment, <jats:sup>14<\/jats:sup>C\u2010urea breath test was performed to evaluate <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and fifty patients (124 patients in <jats:styled-content style=\"fixed-case\">PACT<\/jats:styled-content>\u201010 and 126 patients in <jats:styled-content style=\"fixed-case\">PACT<\/jats:styled-content>\u201014 regimens) completed the study. The intention\u2010to\u2010treat eradication rates were 77.6% (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 70.6\u201384.6%) and 86% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 80\u201392%) for the two regimens, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.17). Per\u2010protocol eradication rates were 83.8% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 80\u201386%) and 92.8% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 88\u201396%), respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). There were no significant intergroup differences in compliance to treatment or discontinuation of therapy due to severe side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ten\u2010day hybrid regimen could not achieve acceptable eradication rate. However, 14\u2010day hybrid regimen seems to be an acceptable option for <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content><\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> eradication in Iran.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12202","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T09:13:34Z","timestamp":1425460414000},"page":"299-304","source":"Crossref","is-referenced-by-count":20,"title":["Comparison Between 10\u2010 and 14\u2010Day Hybrid Regimens for <i><scp>H<\/scp>elicobacter pylori<\/i> Eradication: A Randomized Clinical Trial"],"prefix":"10.1111","volume":"20","author":[{"given":"Hassan Ali","family":"Metanat","sequence":"first","affiliation":[{"name":"Inflammatory Diseases of Upper Gastrointestinal Tract Research Center Department of Gastroenterology Mazandaran University of Medical Sciences Sari Mazandaran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed 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