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C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J mice were intragastrically administered<jats:italic>Lactobacillus<\/jats:italic>strains once daily with 10<jats:sup>8<\/jats:sup>\u201310<jats:sup>9<\/jats:sup>colony\u2010forming units (<jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>), starting 2\u00a0days before intragastric infection with<jats:italic>H.\u00a0suis<\/jats:italic><jats:styled-content style=\"fixed-case\">TKY<\/jats:styled-content>(approximately 1\u00a0\u00d7\u00a010<jats:sup>4<\/jats:sup>copies of 16S<jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content>genes) or<jats:italic>H.\u00a0pylori<\/jats:italic>Sydney strain 1 (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>1; 3\u00a0\u00d7\u00a010<jats:sup>8<\/jats:sup><jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>) and continuing for 14\u00a0days after infection. 2. C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J mice were given powdered feed mixed with lyophilized<jats:italic>L.\u00a0gasseri<\/jats:italic><jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>2055 (<jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content>2055) cells (5\u00a0\u00d7\u00a010<jats:sup>8<\/jats:sup><jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\/g), starting 2\u00a0weeks before intragastric infection with<jats:italic>H.\u00a0suis<\/jats:italic><jats:styled-content style=\"fixed-case\">TKY<\/jats:styled-content>and continuing 12\u00a0months after infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1. Among the 5<jats:italic>Lactobacillus<\/jats:italic>strains that we examined, only<jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content>2055 exhibited significantly preventive efficacy against both<jats:italic>H.\u00a0suis<\/jats:italic><jats:styled-content style=\"fixed-case\">TKY<\/jats:styled-content>and<jats:italic>H.\u00a0pylori<\/jats:italic><jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>1 at day 15 after infection. 2. Dietary supplementation with<jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content>2055 protected mice from the formation of round protrusive lesions in the gastric fundus 12\u00a0months after infection with<jats:italic>H.\u00a0suis<\/jats:italic><jats:styled-content style=\"fixed-case\">TKY<\/jats:styled-content>, whereas such lesions had developed in the gastric fundus of nonsupplemented mice 12\u00a0months after infection. In addition, the formation of lymphoid follicles in gastric mucus layers was suppressed by dietary<jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content>2055 at 3\u00a0months after infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content>2055 administration is effective for suppressing the progression of gastric<jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>lymphoma by reducing<jats:italic>H.\u00a0suis<\/jats:italic>colonization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12203","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T06:10:08Z","timestamp":1422425408000},"page":"291-298","source":"Crossref","is-referenced-by-count":26,"title":["Mouse Models for Assessing the Protective Efficacy of<i>Lactobacillus gasseri<\/i><scp>SBT<\/scp>2055 against<i>Helicobacter suis<\/i>Infection Associated with the Development of Gastric Mucosa\u2010Associated Lymphoid Tissue Lymphoma"],"prefix":"10.1111","volume":"20","author":[{"given":"Hidenori","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Infection Control and Immunology Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences Kitasato University Minato\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsufumi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Center for Clinical Pharmacy and Clinical Sciences School of Pharmaceutical Sciences Kitasato University Minato\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"\u00d8verby","sequence":"additional","affiliation":[{"name":"Center for Clinical Pharmacy and Clinical Sciences School of Pharmaceutical Sciences Kitasato University Minato\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somay Yamagata","family":"Murayama","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology School of Pharmacy Nihon University Funabashi\u2010shi Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruno","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Immunology Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences Kitasato University Minato\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Animal Science School of Veterinary Medicine and Animal Sciences Kitasato University Towada Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Animal Science School of Veterinary Medicine and Animal Sciences Kitasato University Towada Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Seto","sequence":"additional","affiliation":[{"name":"Milk Science Research Institute Megmilk Snow Brand Co., Ltd. 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