{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:25Z","timestamp":1787014285450,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The eradication rate of\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                        elicobacter pylori\n                      <\/jats:italic>\n                      (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                        .\u00a0pylori\n                      <\/jats:italic>\n                      ) infection might be affected by the degree of inflammation of gastric mucosa represented by the endoscopic stage of peptic ulcer disease (\n                      <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                      ). The aims of this study were to evaluate the eradication rates of\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                        .\u00a0pylori\n                      <\/jats:italic>\n                      infection according to the endoscopic stage of\n                      <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                      and to document whether early eradication in the active stage could yield a higher eradication rate in patients with peptic ulcer bleeding (\n                      <jats:styled-content style=\"fixed-case\">PUB<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 1,177 patients with\n                      <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                      (380 gastric ulcer, 710 duodenal ulcer, and 87 combined ulcer) who received proton\u2010pump inhibitor (\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      )\u2010based triple therapy were included, and the eradication rates were compared by ulcer stage. Univariate and multivariate analyses were conducted to identify factors influencing eradication rate. In\n                      <jats:styled-content style=\"fixed-case\">PUB<\/jats:styled-content>\n                      , the eradication rates between the early eradication group (\u22647\u00a0days) and the late eradication group (&gt;7\u00a0days) were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The eradication rates according to endoscopic stage were significantly different in gastric ulcer (active vs healing vs scarring; 84.8% vs 82.7% vs 70.6%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .014, respectively), but there were no significant differences in duodenal ulcer (active vs healing vs scarring; 87.6% vs 80.9%% vs 80.9%\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .169, respectively). In multivariate analyses, active ulcer as well as age younger than 50 was a significantly independent predictor of successful eradication (Odds ratio; 2.799, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ; 1.659\u20134.723,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .0001). The eradication rate of the early eradication group was significantly higher than the late eradication group in\n                      <jats:styled-content style=\"fixed-case\">PUB<\/jats:styled-content>\n                      (89.2% vs 71.9%, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ; 1.265\u20138.269,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      There was a significant difference in the eradication rate according to the endoscopic stage of gastric ulcer. Active ulcer was an independent predictor of successful eradication. Furthermore, early\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      eradication should be considered in patients with\n                      <jats:styled-content style=\"fixed-case\">PUB<\/jats:styled-content>\n                      to yield a higher eradication rate.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12221","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T23:44:01Z","timestamp":1425599041000},"page":"424-430","source":"Crossref","is-referenced-by-count":10,"title":["Is There Any Difference in the Eradication Rate of\n                    <i>\n                      <scp>H<\/scp>\n                      elicobacter pylori\n                    <\/i>\n                    Infection According to the Endoscopic Stage of Peptic Ulcer Disease?"],"prefix":"10.1111","volume":"20","author":[{"given":"Seung In","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon Geon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Kuk","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Heon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Yang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine 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