{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:17:58Z","timestamp":1781893078396,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>Object<\/jats:title>As nonmicrobial dietary approach is capable of controlling H<\/jats:styled-content>elicobacter pylori<\/jats:italic> infection, we evaluated the efficacy of long\u2010term dietary administration of A<\/jats:styled-content>rtemisia<\/jats:italic> and\/or green tea extracts on H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010initiated, high\u2010salt\u2010promoted chronic atrophic gastritis and gastric tumorigenesis mouse model.<\/jats:p><\/jats:sec>Methods<\/jats:title>Helicobacter pylori<\/jats:italic>\u2010infected and high\u2010salt\u2010diet\u2010administered C<\/jats:styled-content>57BL<\/jats:styled-content>\/6 mice were administered with A<\/jats:styled-content>rtemisia<\/jats:italic> extracts (MP<\/jats:styled-content> group) and\/or green tea extracts (GT<\/jats:styled-content> group) for 36\u00a0weeks in addition to the control group (ES<\/jats:styled-content> group, gastroprotective drug, ecabet sodium 30\u00a0mg\/kg, diet pellet). Gross and pathological gastric lesions were evaluated after 24 and 36\u00a0weeks, respectively, and their underlying molecular changes were measured in gastric homogenates. Detailed mechanisms were further evaluated in in vitro cell models.<\/jats:p><\/jats:sec>Results<\/jats:title>The erythematous and nodular changes and mucosal ulcerative and erosive lesions were noted in the control group at 24\u00a0weeks. MP<\/jats:styled-content>, GT<\/jats:styled-content>, MPGT<\/jats:styled-content>, and ES<\/jats:styled-content> groups all showed significantly ameliorated pathologic lesion compared to the control group (p\u00a0<\u00a0<\/jats:italic>.05). After the 36\u00a0weeks, scattered nodular masses with some central ulcers and thin gastric surface were noted in the control stomach, whereas no tumorous lesion and milder atrophic changes were observed in all MP<\/jats:styled-content>, GT<\/jats:styled-content>, and MPGT<\/jats:styled-content> groups except ES<\/jats:styled-content> group (p\u00a0<\u00a0<\/jats:italic>.05). On molecular analysis, increased expressions of COX<\/jats:styled-content>\u20102, TNF<\/jats:styled-content>\u2010\u03b1, IL<\/jats:styled-content>\u20106, lipid peroxide, and activated STAT<\/jats:styled-content>3 relevant to H.\u00a0pylori<\/jats:italic> infection were significantly decreased with MPGT<\/jats:styled-content> administration (p\u00a0<\/jats:italic><\u00a0.01), whereas HSP<\/jats:styled-content>70 was significantly increased. PGDH<\/jats:styled-content> expressions, core tumor suppressor involved in carcinogenesis, were significantly decreased with H.\u00a0pylori<\/jats:italic> infection (p<\/jats:italic>\u00a0<\u00a0.05), but significantly increased in MPGT<\/jats:styled-content> group (p<\/jats:italic>\u00a0<\u00a0.05). Increased mucosal apoptotic index noted in the control group was significantly decreased with MP<\/jats:styled-content> and\/or GT<\/jats:styled-content> along with significantly preserved gastric gastroprotective mediators (p<\/jats:italic>\u00a0<\u00a0.01) such as mucins, HSP<\/jats:styled-content>27, and HSP<\/jats:styled-content>70. H.\u00a0pylori<\/jats:italic>\u2010induced serum TNF<\/jats:styled-content>\u2010\u03b1 and NF<\/jats:styled-content>\u2010\u03baB activations were significantly decreased with MPGT<\/jats:styled-content> administration (p\u00a0<\/jats:italic><\u00a0.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Long\u2010term dietary intake of MP<\/jats:styled-content> and\/or GT<\/jats:styled-content> can be an effective strategy either to rejuvenate H.\u00a0pylori<\/jats:italic> atrophic gastritis or to suppress tumorigenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12229","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T23:01:15Z","timestamp":1428706875000},"page":"40-59","source":"Crossref","is-referenced-by-count":31,"title":["Dietary Intervention of Artemisia<\/i> and Green Tea Extracts to Rejuvenate Helicobacter pylori<\/i>\u2010Associated Chronic Atrophic Gastritis and to Prevent Tumorigenesis"],"prefix":"10.1111","volume":"21","author":[{"given":"Migyeong","family":"Jeong","sequence":"first","affiliation":[{"name":"CHA Cancer Prevention Research Center CHA Bio Complex CHA University Pangyo Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Min","family":"Park","sequence":"additional","affiliation":[{"name":"CHA Cancer Prevention Research Center CHA Bio Complex CHA University Pangyo Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Min","family":"Han","sequence":"additional","affiliation":[{"name":"CHA Cancer Prevention Research Center CHA Bio Complex CHA University Pangyo Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napapan","family":"Kangwan","sequence":"additional","affiliation":[{"name":"CHA Cancer Prevention Research Center CHA Bio Complex CHA University Pangyo 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