{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:20:27Z","timestamp":1778055627486,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> is responsible for most peptic ulcers, plays a role in functional dyspepsia and is thought by some to influence the course of gastroesophageal reflux disease. This article addresses recent studies that have been published in connection with these diseases. <jats:italic>H. pylori<\/jats:italic>\u2010associated peptic ulcer is declining in prevalence but the incidence of perforation and bleeding remains high especially in the elderly. All <jats:italic>H. pylori<\/jats:italic> associated peptic ulcers should be treated by eradication of the infection. Dyspepsia is a common disorder that affects up to 25% of the population. About 8% of cases that are infected with <jats:italic>H. pylori<\/jats:italic> will respond to treatment of the infection. The association between <jats:italic>H. pylori<\/jats:italic> and gastroesophageal reflux disease continues to be debated, a number of studies have shown that there is a negative association between <jats:italic>H. pylori<\/jats:italic> infection and Gastroesophageal reflux disease but treatment of <jats:italic>H. pylori<\/jats:italic> has not been shown to induce reflux or to affect the response to medication. Gastric atrophy is known to extend when acid suppression is used in infected patients implying that <jats:italic>H. pylori<\/jats:italic> treatment should be used in infected patients who are to undergo long\u2010term Proton Pump Inhibitor therapy.<\/jats:p>","DOI":"10.1111\/hel.12253","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T22:39:17Z","timestamp":1442356757000},"page":"26-29","source":"Crossref","is-referenced-by-count":16,"title":["<i>Helicobacter pylori<\/i> and Nonmalignant Diseases"],"prefix":"10.1111","volume":"20","author":[{"given":"Georgios S.","family":"Potamitis","sequence":"first","affiliation":[{"name":"Potamitis Gastroenterology\u2010Nutrition Center Apollonion Private Hospital Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony T. R.","family":"Axon","sequence":"additional","affiliation":[{"name":"Axon Nidd Park House Nidd North Yorkshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3320"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"S116","article-title":"Helicobacter pylori","volume":"89","author":"Marshall BJ","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.02.026"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.11.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03960.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724100-00003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04563.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i18.5191"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.08.010"},{"key":"e_1_2_6_12_1","first-page":"1503","article-title":"Helicobacter pylori and gastric cancer: Indian enigma World","volume":"20","author":"Misra V","year":"2014","journal-title":"J Gastroenterol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032015000100010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032014000200016"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i46.17568"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2014.55.647"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07273-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323958"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.2"},{"key":"e_1_2_6_20_1","first-page":"9439","article-title":"Interaction between Helicobacter pylori infection, nonsteroidal anti\u2010inflammatory drugs and\/or low\u2010dose aspirin use: old question new insights","volume":"20","author":"Sostres C","year":"2014","journal-title":"World J Gastroenterol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.057"},{"key":"e_1_2_6_23_1","first-page":"8957","article-title":"Helicobacter pylori and functional dyspepsia: an unsolved issue?","volume":"20","author":"Zullo A","year":"2014","journal-title":"World J Gastroenterol"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.08724.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31829f2e25"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06649.x"},{"key":"e_1_2_6_27_1","first-page":"CD 002096N","article-title":"Eradication of Helicobacter pylori for non\u2010ulcer dyspepsia","author":"Moayyedi P","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3285-1"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05982.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06635.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000085"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00466.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.3.267"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.08.010"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.734"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.155049"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.08.029"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-375"},{"key":"e_1_2_6_40_1","first-page":"8979","article-title":"Helicobacter pylori: friend or foe?","volume":"20","author":"Malnick SD","year":"2014","journal-title":"World J Gastroenterol"},{"key":"e_1_2_6_41_1","first-page":"ID 985249","article-title":"Helicobacter pylori infection in gastroesophageal reflux disease in the Asian countries","author":"Hong SJ","year":"2015","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000429"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12253","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T23:20:16Z","timestamp":1694474416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":41,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/hel.12253"],"URL":"https:\/\/doi.org\/10.1111\/hel.12253","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}