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Indeed, <jats:italic>H.\u00a0pylori<\/jats:italic> may interfere with many biological processes, both inside and outside of the stomach, possibly influencing or determining the occurrence of many diseases outside of the stomach. While its role in idiopathic thrombocytopenic purpura and sideropenic anemia has already been recognized, emerging evidence suggests that <jats:italic>H.\u00a0pylori<\/jats:italic> may increase the risk of acute coronary syndrome, contribute to insulin resistance and be associated with neurodegenerative, respiratory, and other miscellaneous disorders previously associated with other conditions. Different pathogenic mechanisms have been hypothesized, including the induction of a low\u2010grade inflammatory state and the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic in the last year.<\/jats:p>","DOI":"10.1111\/hel.12256","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T22:39:17Z","timestamp":1442356757000},"page":"40-46","source":"Crossref","is-referenced-by-count":130,"title":["Extragastric Diseases and <i>Helicobacter pylori<\/i>"],"prefix":"10.1111","volume":"20","author":[{"given":"Francesco","family":"Franceschi","sequence":"first","affiliation":[{"name":"Internal Medicine Institute Catholic University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[{"name":"Internal Medicine and Gastroenterology Catholic University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stergios A.","family":"Polyzos","sequence":"additional","affiliation":[{"name":"Department of Medicine Second Medical 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