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After antibiotic withdrawal, weanlings were gavaged with four H<\/jats:styled-content>.\u00a0bilis<\/jats:italic>\u2010like H<\/jats:styled-content>elicobacter<\/jats:italic> spp. isolated from hamsters or H<\/jats:styled-content>.\u00a0bilis <\/jats:italic>ATCC<\/jats:styled-content> 43879 isolated from human feces and compared to controls (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>7 per group).<\/jats:p><\/jats:sec>Results<\/jats:title>Helicobacter bilis<\/jats:italic> 43879\u2010dosed hamsters were necropsied at 33 weeks postinfection (WPI<\/jats:styled-content>) due to the lack of detectable infection by fecal PCR<\/jats:styled-content>; at necropsy, 5 of 7 were weakly PCR<\/jats:styled-content> positive but lacked intestinal lesions. The remaining hamsters were maintained for ~95 WPI<\/jats:styled-content>; chronic H<\/jats:styled-content><\/jats:italic>. spp. infection in hamsters (6\/7) was confirmed by PCR<\/jats:styled-content>, bacterial culture, fluorescent in\u00a0situ<\/jats:italic> hybridization, and ELISA<\/jats:styled-content>. Hamsters had mild\u2010to\u2010moderate typhlitis, and three of the male H<\/jats:styled-content><\/jats:italic>. spp.\u2010infected hamsters developed small intestinal lymphoma, in contrast to one control. Of the three lymphomas in H<\/jats:styled-content><\/jats:italic>. spp.\u2010infected hamsters, one was a focal ileal mucosa\u2010associated lymphoid tissue (MALT<\/jats:styled-content>) B<\/jats:styled-content>\u2010cell lymphoma, while the other two were multicentric small intestinal large B<\/jats:styled-content>\u2010cell lymphomas involving both the MALT<\/jats:styled-content> and extra\u2010MALT<\/jats:styled-content> mucosal sites with lymphoepithelial lesions. The lymphoma in the control hamster was a diffuse small intestinal lymphoma with a mixed population of T<\/jats:styled-content> and B<\/jats:styled-content> cells.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Results suggest persistent H<\/jats:styled-content><\/jats:italic>. spp. infection may augment risk\u00a0for gastrointestinal MALT<\/jats:styled-content> origin lymphomas. This model is consistent with H<\/jats:styled-content>.\u00a0pylori\/heilmannii<\/jats:italic>\u2010associated MALT<\/jats:styled-content> lymphoma in humans and could be further utilized to investigate the mechanisms of intestinal lymphoma development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12265","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T12:43:25Z","timestamp":1441716205000},"page":"201-217","source":"Crossref","is-referenced-by-count":7,"title":["Male Syrian Hamsters Experimentally Infected with H<\/scp>elicobacter<\/i> spp. of the H<\/scp>.\u00a0bilis<\/i> Cluster Develop MALT<\/scp>\u2010Associated Gastrointestinal Lymphomas"],"prefix":"10.1111","volume":"21","author":[{"given":"Stephanie E.","family":"Woods","sequence":"first","affiliation":[{"name":"Division of Comparative Medicine Massachusetts Institute of Technology Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Ek","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine Massachusetts Institute of Technology Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeli","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine Massachusetts Institute of Technology Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine Massachusetts Institute of Technology Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongming","family":"Ge","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine Massachusetts Institute of Technology Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sureshkumar","family":"Muthupalani","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine Massachusetts Institute of Technology Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark T.","family":"Whary","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine Massachusetts Institute of Technology Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Fox","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine Massachusetts Institute of Technology Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-42-1-27"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00939.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.2.445-454.1995"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-47-3-627"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/019262339802600503"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.8.3126-3131.1997"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.5.1548-1558.1996"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.9.3673-3681.1996"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5157-5166.1998"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.16.1222"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.5.1811-1817.2000"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.11.2940-2947.1995"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.27.7.1692-1694.1989"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-3-386"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1128\/JCM.38.10.3722-3728.2000","article-title":"Helicobacter aurati sp. nov., a urease\u2010positive Helicobacter species cultured from gastrointestinal tissues of Syrian hamsters","volume":"38","author":"Patterson MM","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-6-589"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.34.12.2952-2958.1996"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-1-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00879-09"},{"key":"e_1_2_6_21_1","unstructured":"IARC.Opisthorchis viverrini and Clonorchis sinensis. 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