{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:04:44Z","timestamp":1789110284348,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> causes chronic gastritis, gastroduodenal ulcers, and gastric cancer, and has been treated with two antibiotics (amoxicillin and clarithromycin) and proton\u2010pump inhibitors (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>s). However, antibiotic treatment alters the indigenous gut microbiota to cause side effects. Therefore, the effects of probiotic supplementation on therapy have been studied. Although several studies have covered the probiotics\u2019 effects, details about the gut microbiota changes after <jats:italic>H. pylori<\/jats:italic> eradication have not been evaluated. Therefore, we analyzed the influences of antibiotics and their combination with probiotics on the composition of the gut microbiota using high\u2010throughput sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were divided into two groups. The antibiotics group was treated with general therapy, and the probiotics group with general therapy and probiotic supplementation. Fecal samples were collected from all subjects during treatments, and the influences on gut microbiota were analyzed by 16S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content> gene\u2010pyrosequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three phyla, Firmicutes, Bacteroidetes, and Proteobacteria, were predominant in the gut microbiota of all subjects. After treatment, the relative abundances of Firmicutes were reduced, whereas those of Proteobacteria were increased in both groups. However, the changed proportions of the gut microbiota in the antibiotics group were higher than those in the probiotics group. In addition, the increase in the levels of antibiotic\u2010resistant bacteria was higher in the antibiotics group than in the probiotics one.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Probiotic supplementation can reduce the antibiotic\u2010induced alteration and imbalance of the gut microbiota composition. This effect may restrict the growth of antibiotic\u2010resistant bacteria in the gut and improve the <jats:italic>H. pylori<\/jats:italic> eradication success rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12270","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T13:01:38Z","timestamp":1443013298000},"page":"165-174","source":"Crossref","is-referenced-by-count":147,"title":["The Effect of Probiotics on Gut Microbiota during the <i>Helicobacter pylori<\/i> Eradication: Randomized Controlled Trial"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-0755","authenticated-orcid":false,"given":"Bumjo","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Family Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Hallym University Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenteology Seoul National University Boramae Hospital Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Joon","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenteology Seoul National University Boramae Hospital Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong Gwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenteology Seoul National University Boramae Hospital Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kook Lae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenteology Seoul National University Boramae Hospital Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongsik","family":"Chun","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Seoul National University Seoul Korea"},{"name":"Chunlab Inc. Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a018040"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3174"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2014.29.5.704"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12075"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2012.00981.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i42.7476"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2013-0490"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2014.08.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.3507"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i3.673"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111030"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009836"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.035"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2014.12.3.178"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183605"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.05490-11"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.06102-11"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-013-0401-y"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002195"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.038075-0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr381"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01541-09"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2144\/03342mt01"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.040618-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.4.1365-1368.2004"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114514001135"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01061694"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70003-5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7226.31"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i18.5283"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016879"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47615-0"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.08.034"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i33.11878"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095476"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(99)00808-4"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i41.15163"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2015.05.001"},{"key":"e_1_2_6_41_1","article-title":"Anti\u2010TNF treatment with adalimumab induces changes in the microbiota of Crohn's disease","author":"David B","year":"2015","journal-title":"J Crohns Colitis."}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T10:53:27Z","timestamp":1695725607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,23]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/hel.12270"],"URL":"https:\/\/doi.org\/10.1111\/hel.12270","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,23]]}}}