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Both the Maastricht <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\/Florence consensus report and the Kyoto global consensus report have proposed the eradication of <jats:italic>H. pylori<\/jats:italic> to prevent gastric cancer as <jats:italic>H.pylori<\/jats:italic> has been shown to be a major cause of gastric carcinogenesis. The interactions between <jats:italic>H. pylori<\/jats:italic> and host receptors induce the release of the proinflammatory cytokines by activating proinflammatory signaling pathways such as nuclear factor kappa B (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB), which plays a central role in inflammation, immune response, and carcinogenesis. Among these receptors, Toll\u2010like receptors (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s) are classical pattern recognition receptors in the recognition of <jats:italic>H. pylori<\/jats:italic> and the mediation of the host inflammatory and immune responses to <jats:italic>H. pylori<\/jats:italic>. <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content> polymorphisms also contribute to the clinical consequences of <jats:italic>H. pylori<\/jats:italic> infection. In this review, we focus on the functions of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s in the <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB signaling pathway activated by <jats:italic>H. pylori<\/jats:italic>, the regulators modulating this response, and the functions of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content> polymorphisms in <jats:italic>H.pylori<\/jats:italic>\u2010related diseases.<\/jats:p>","DOI":"10.1111\/hel.12292","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T08:52:30Z","timestamp":1452761550000},"page":"428-440","source":"Crossref","is-referenced-by-count":35,"title":["The Importance of Toll\u2010like Receptors in <scp>NF<\/scp>\u2010\u03baB Signaling Pathway Activation by <i>Helicobacter pylori<\/i> Infection and the Regulators of this Response"],"prefix":"10.1111","volume":"21","author":[{"given":"Yi","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Nutrition Karolinska Institute Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nong\u2010Hua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00874.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-10"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"},{"key":"e_1_2_6_6_1","first-page":"1","article-title":"Schisto\u2010somes, liver flukes and Helicobacter pylori. 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