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In this study, we investigated the effects of <jats:italic>H. pylori<\/jats:italic> infection on the expressions and functional activities of human duodenal mucosal bicarbonate transport proteins and hope to further clarify the pathogenesis of <jats:italic>H. pylori<\/jats:italic>\u2010associated duodenal ulcer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The experiments were performed in the patients with <jats:italic>H. pylori<\/jats:italic>\u2010associated duodenal ulcers, <jats:italic>H. pylori<\/jats:italic>\u2010associated chronic gastritis, and <jats:italic>H. pylori\u2010<\/jats:italic>negative healthy subjects. Duodenal mucosal bicarbonate secretion was measured by Ussing Chamber technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expressions of duodenal mucosal bicarbonate transport proteins, <jats:styled-content style=\"fixed-case\">CFTR<\/jats:styled-content> (cystic fibrosis transmembrane conductance regulator) and <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>26A6 (solute\u2010linked carrier 26 gene A6), in the patients with <jats:italic>H. pylori<\/jats:italic>\u2010associated duodenal ulcers were markedly lower than those in healthy controls. Basal and both forskolin\u2010 and prostaglandin E<jats:sub>2<\/jats:sub>\u2010stimulated duodenal mucosal bicarbonate secretions in the patients with <jats:italic>H. pylori<\/jats:italic>\u2010associated duodenal ulcers were also lower than those in healthy controls. After anti\u2010<jats:italic>H. pylori<\/jats:italic> treatment for <jats:italic>H. pylori<\/jats:italic>\u2010associated duodenal ulcers, duodenal mucosal bicarbonate secretion and <jats:styled-content style=\"fixed-case\">CFTR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>26A6 expressions in <jats:italic>H. pylori<\/jats:italic>\u2010eradicated patients recovered to levels comparable to healthy controls, but those were found to be not significantly altered in non\u2010<jats:italic>H. pylori<\/jats:italic>\u2010eradicated patients. The further results showed that decreases in the <jats:italic>H. pylori<\/jats:italic>\u2010induced <jats:styled-content style=\"fixed-case\">CFTR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>26A6 expression were related to the severity and virulent factors of <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic> infection impairs the expressions and functional activities of duodenal mucosal bicarbonate transport proteins, <jats:styled-content style=\"fixed-case\">CFTR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>26A6, which contributes to the development of duodenal ulcer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12309","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T13:01:07Z","timestamp":1458738067000},"page":"536-547","source":"Crossref","is-referenced-by-count":8,"title":["Effects of <i>Helicobacter pylori<\/i> Infection on the Expressions and Functional Activities of Human Duodenal Mucosal Bicarbonate Transport Proteins"],"prefix":"10.1111","volume":"21","author":[{"given":"Guorong","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital Zunyi Medical College Zunyi China"},{"name":"Digestive Disease Institute of Guizhou Province Zunyi China"},{"name":"Research Center of Medicine and Biology Zunyi Medical College Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital Zunyi Medical College Zunyi 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