{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:22:01Z","timestamp":1789640521468,"version":"4.0.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence is lacking regarding how<jats:italic>Helicobacter pylori<\/jats:italic>infection status, eradication history, and<jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>blood type affect the development of gastric cancer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>) given the multifactorial and distinctive etiology according to cancer location (noncardia vs cardia) and histologic type (intestinal vs diffuse\u2010type). We evaluated the effect of<jats:italic>H. pylori<\/jats:italic>infection status incorporated with<jats:italic>H. pylori<\/jats:italic>eradication history and<jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>genotype on<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>development according to cancer location and histologic type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study of 997 patients with noncardia<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">NCGC<\/jats:styled-content>) and 1147 control subjects was performed using risk analyses with 14 factors including<jats:italic>H. pylori<\/jats:italic>infection with eradication history and<jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>genotype. As final analyses, multivariable logistic regression models were fitted. Additionally,<jats:italic>H. pylori<\/jats:italic>infection status with eradication history was tested for its association with age, atrophic gastritis (<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>), and intestinal metaplasia (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The<jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>genotype with the B allele was associated with a significantly lower risk of<jats:styled-content style=\"fixed-case\">NCGC<\/jats:styled-content>of both histologic types. The reduction in risk for<jats:styled-content style=\"fixed-case\">NCGC<\/jats:styled-content>by adding the B allele was more prominent in diffuse\u2010type than that in the intestinal\u2010type.<jats:italic>H. pylori<\/jats:italic>infection with eradication history was associated with a significantly lower risk of<jats:styled-content style=\"fixed-case\">NCGC<\/jats:styled-content>of both histologic types, compared with those without eradication history (odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>), 0.22; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 0.14\u20130.34) approaching that of uninfected subjects. Past infection status without an eradication history was associated with older age,<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic>eradication and the B allele decreased the risks of the intestinal and diffuse\u2010types of<jats:styled-content style=\"fixed-case\">NCGC<\/jats:styled-content>.<jats:italic>H. pylori<\/jats:italic>eradication revealed a strong association against developing<jats:styled-content style=\"fixed-case\">NCGC<\/jats:styled-content>. Therefore, it should be considered as a primary measure in<jats:styled-content style=\"fixed-case\">NCGC<\/jats:styled-content>prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12317","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T13:44:18Z","timestamp":1463579058000},"page":"596-605","source":"Crossref","is-referenced-by-count":25,"title":["Effect of<i>Helicobacter pylori<\/i>Eradication and<scp>ABO<\/scp>Genotype on Gastric Cancer Development"],"prefix":"10.1111","volume":"21","author":[{"given":"Sooyeon","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Won","family":"Kwon","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Min","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Chae","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul 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