{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:46:54Z","timestamp":1787662014071,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:00:00Z","timestamp":1466640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","award":["FIS\/IMSS\/PROT\/G09\/768"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G09\/768"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Polymorphisms in inflammation\u2010related genes are factors associated with the development of gastroduodenal diseases in\n                      <jats:italic>Helicobacter pylori\u2010<\/jats:italic>\n                      infected individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We aimed to analyze polymorphisms in\n                      <jats:italic>HLA\u2010DQ<\/jats:italic>\n                      , together with other host and\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      variables as risk factors for precancerous and cancerous gastric lesions. 1052 individuals were studied, including nonatrophic gastritis (NAG), intestinal metaplasia (IM), gastric cancer (GC) or duodenal ulcer (DU) patients, and healthy volunteers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with alleles DQA*01:01 (OR 0.78), *01:02 (OR 0.29), *01:03 (OR 0.31), and DQB*02:01\/02 (OR 0.40) showed a reduced risk for GC. A multivariate logistic regression analyses showed that patients with homozygote genotypes DQA1*03:01 (OR 7.27) and DQA1*04:01 (OR 8.99) and DQB1*05:01:01 (OR 12.04) were at significantly increased risk for GC. Multivariate analyses also demonstrated that age (OR&gt;10.0) and gender (OR&gt;2.0) were variables that influenced significantly the risk for GC, while\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      infection (OR&gt;2.5) increased the risk for IM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We identified HLA\u2010DQ alleles associated with IM and GC, and confirm that age, sex, and\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      infection are variables that also influence the risk for disease. The use of multiple markers, HLA\u2010DQ alleles, age, sex, and\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      infection may be useful biomarkers for the early diagnosis of patients with IM and GC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12326","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T07:53:24Z","timestamp":1466754804000},"source":"Crossref","is-referenced-by-count":21,"title":["Polymorphisms in\n                    <i>HLA\u2010DQ<\/i>\n                    genes, together with age, sex, and\n                    <i>Helicobacter pylori<\/i>\n                    infection, as potential biomarkers for the early diagnosis of gastric cancer"],"prefix":"10.1111","volume":"22","author":[{"given":"Martha","family":"P\u00e9rez\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Immunology Research Unit CMN S\u2010XXI, IMSS  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo","family":"Partida\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Immunology Research Unit CMN S\u2010XXI, IMSS  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Camorlinga\u2010Ponce","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Unit CMN S\u2010XXI, IMSS  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Flores\u2010Luna","sequence":"additional","affiliation":[{"name":"Research Center in Health Population National Institute of Public Health  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Lazcano","sequence":"additional","affiliation":[{"name":"Research Center in Health Population National Institute of Public Health  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Unit CMN S\u2010XXI, IMSS  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Herrera\u2010Goepfert","sequence":"additional","affiliation":[{"name":"Department of Pathology National Institute for Cancer  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Medrano\u2010Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Sarcomas UMAE Oncology CMN S\u2010XXI, IMSS Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Torres","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Unit CMN S\u2010XXI, IMSS  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,23]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"FerlayJ SoerjomataramI ErvikM et\u00a0al.GLOBOCAN 2012 v1.0 Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11[Internet]. vol.Lyon France:International Agency for Research on Cancer;2013.http:\/\/globocan.iarc.fr. 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