{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:56:28Z","timestamp":1789656988457,"version":"4.0.1"},"reference-count":65,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Science Foundation","award":["CRC-796"],"award-info":[{"award-number":["CRC-796"]}]},{"name":"German Science Foundation","award":["CRC-1181"],"award-info":[{"award-number":["CRC-1181"]}]},{"name":"German Science Foundation","award":["CRC-854"],"award-info":[{"award-number":["CRC-854"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is estimated to infect more than half of the worlds human population and represents a major risk factor for chronic gastritis, peptic ulcer disease,\n                    <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>\n                    lymphoma, and gastric adenocarcinoma.\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    infection and clinical consequences are controlled by highly complex interactions between the host, colonizing bacteria, and environmental parameters. Important bacterial determinants linked with gastric disease development include the\n                    <jats:italic>cag<\/jats:italic>\n                    pathogenicity island encoding a type\n                    <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                    secretion system (T4\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    ), the translocated effector protein CagA, vacuolating cytotoxin VacA, adhesin BabA, urease, serine protease HtrA, secreted outer membrane vesicles, and many others. The high quantity of these factors and allelic changes in the corresponding genes reveals a sophisticated picture and problems in evaluating the impact of each distinct component. Extensive work has been performed to pinpoint molecular processes related to\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    \u2010triggered pathogenesis using Mongolian gerbils, mice, primary tissues, as well as novel in vitro model systems such as gastroids. The manipulation of host signaling cascades by the bacterium appears to be crucial for inducing pathogenic downstream activities and gastric disease progression. Here, we review the most recent advances in this important research area.\n                  <\/jats:p>","DOI":"10.1111\/hel.12335","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T21:15:31Z","timestamp":1471382131000},"page":"19-25","source":"Crossref","is-referenced-by-count":104,"title":["Pathogenesis of\n                    <i>Helicobacter pylori<\/i>\n                    infection"],"prefix":"10.1111","volume":"21","author":[{"given":"Steffen","family":"Backert","sequence":"first","affiliation":[{"name":"Division of Microbiology Department of Biology Friedrich Alexander University Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Neddermann","sequence":"additional","affiliation":[{"name":"Division of Microbiology Department of Biology Friedrich Alexander University Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Maubach","sequence":"additional","affiliation":[{"name":"Institute of Experimental Internal Medicine Otto von Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Naumann","sequence":"additional","affiliation":[{"name":"Institute of Experimental Internal Medicine Otto von Guericke University  Magdeburg 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