{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:25:44Z","timestamp":1762521944301},"reference-count":27,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peptic ulcer disease (PUD) has been further decreased over the last decades along with decreasing prevalence of <jats:italic>Helicobacter pylori<\/jats:italic>\u2010associated PUD. A delayed <jats:italic>H.\u00a0pylori<\/jats:italic> eradication has been associated with an increased risk of rehospitalization for complicated recurrent peptic ulcer and reemphasized the importance of eradication especially in patients with peptic ulcer bleeding (PUB). PUB associated with NSAID\/aspirin intake and <jats:italic>H.\u00a0pylori<\/jats:italic> revealed an additive interaction in gastric pathophysiology which favors the \u201ctest\u2010and\u2010treat\u201d strategy for <jats:italic>H.\u00a0pylori<\/jats:italic> in patients with specific risk factors. The <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative and NSAID\u2010negative \u201cidiopathic PUD\u201d have been increasingly observed and associated with slower healing tendency, higher risk of recurrence, and greater mortality. <jats:italic>Helicobacter pylori<\/jats:italic>\u2010associated dyspepsia has been further investigated and finally defined by the Kyoto consensus. <jats:italic>Helicobacter pylori<\/jats:italic> eradication therapy is advised as first option in this group of patients. Only in the case of symptom persistence or recurrence after eradication therapy, dyspeptic patients should be classified as functional dyspepsia (FD). There were few new data in 2015 on the role of <jats:italic>H.\u00a0pylori<\/jats:italic> infection in gastroesophageal reflux disease (GERD), and in particular Barrett's esophagus. A lower prevalence of gastric atrophy with less acid output in patients with erosive esophagitis confirmed previous findings. In patients with erosive esophagitis, no difference was observed in healing rates neither between <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive and <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative patients nor between patients that underwent eradication therapy compared to patients without eradication. These findings are in line with the current consensus guidelines concluding that <jats:italic>H.\u00a0pylori<\/jats:italic> eradication has no effects on symptoms and does not aggravate preexisting GERD.<\/jats:p>","DOI":"10.1111\/hel.12337","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T01:15:31Z","timestamp":1471396531000},"page":"30-33","source":"Crossref","is-referenced-by-count":15,"title":["<i>Helicobacter pylori<\/i> and non\u2010malignant upper gastrointestinal diseases"],"prefix":"10.1111","volume":"21","author":[{"given":"Riccardo","family":"Vasapolli","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University Hospital  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Malfertheiner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University Hospital  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Kandulski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University Hospital  Magdeburg 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