{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:03:25Z","timestamp":1787065405329,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["92\u20103"],"award-info":[{"award-number":["92\u20103"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n An association exists between\n Helicobacter pylori<\/jats:italic>\n (\n H. pylori<\/jats:italic>\n ), peptic ulcers, gastritis, and sometimes gastric carcinomas. Th22 cells have protective and inflammatory roles in defense against microbes.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n We investigated the frequencies of Th22, Tc22, Th22\/17, and Tc22\/17 cells in addition to the changes in levels of cytokines\n IL<\/jats:styled-content>\n \u201022,\n IL<\/jats:styled-content>\n \u20106,\n IL<\/jats:styled-content>\n \u201023,\n TNF<\/jats:styled-content>\n \u2010\u03b1,\n IL<\/jats:styled-content>\n \u20101\u03b2, and\n TGF<\/jats:styled-content>\n \u2010\u03b2 in sera from patients with\n H. pylori<\/jats:italic>\n \u2010associated gastritis, and peptic ulcer, and in uninfected patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 76 patients with\n H. pylori\u2010<\/jats:italic>\n associated disorders formed the studied group. Frequencies of T\u2010cell subsets were determined by flow cytometry. Levels of cytokines\n IL<\/jats:styled-content>\n \u201022,\n IL<\/jats:styled-content>\n \u20106,\n IL<\/jats:styled-content>\n \u201023,\n TNF<\/jats:styled-content>\n \u2010\u03b1,\n IL<\/jats:styled-content>\n \u20101\u03b2, and\n TGF<\/jats:styled-content>\n \u2010\u03b2 in the sera and supernatants of patients were measured by\n ELISA<\/jats:styled-content>\n and flow cytometry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study participants included 32 males and 44 females with a mean age of 38.5\u00b115.3\u00a0years. We divided the infected group into peptic ulcer and gastritis (mild, moderate, active chronic, and chronic). The frequencies of Th22, Tc22, and Tc22\/17 increased significantly in the peptic ulcer, moderate, active chronic, and chronic gastritis groups compared to the uninfected group. Th22\/17 only increased significantly in the chronic gastritis group. We observed significant increases in\n IL<\/jats:styled-content>\n \u201022 in the moderate and active chronic gastritis,\n IL<\/jats:styled-content>\n \u201023 in the active chronic and chronic gastritis, and\n TNF<\/jats:styled-content>\n \u2010\u03b1 in the peptic ulcer and moderate gastritis groups. Following in vitro antigenic stimulation, we observed significantly higher levels of\n IL<\/jats:styled-content>\n \u20101\u03b2,\n IL<\/jats:styled-content>\n \u201023, and\n IL<\/jats:styled-content>\n \u20106 in the active chronic gastritis group, as well as\n IL<\/jats:styled-content>\n \u20106 and\n IL<\/jats:styled-content>\n \u20101\u03b2 in the chronic gastritis group compared to the uninfected group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Increased Th22, Tc22, and Tc22\/17 cells and\n IL<\/jats:styled-content>\n \u201022 levels appear to be influential in progression and severity of\n H. pylori<\/jats:italic>\n infection. Th22\/17 can be an interesting therapeutic target for chronic\n H. pylori<\/jats:italic>\n infections where eradication is more difficult.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.12367","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T04:12:43Z","timestamp":1482120763000},"source":"Crossref","is-referenced-by-count":11,"title":["The importance of\n TH<\/scp>\n 22 and\n TC<\/scp>\n 22 cells in the pathogenesis of\n Helicobacter pylori\u2010<\/i>\n associated gastric diseases"],"prefix":"10.1111","volume":"22","author":[{"given":"Seyedeh Azra","family":"Shamsdin","sequence":"first","affiliation":[{"name":"Prof. Alborzi Clinical Microbiology Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Gastroenterohepatology Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolvahab","family":"Alborzi","sequence":"additional","affiliation":[{"name":"Prof. Alborzi Clinical Microbiology Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoochehr","family":"Rasouli","sequence":"additional","affiliation":[{"name":"Prof. Alborzi Clinical Microbiology Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Ghaderi","sequence":"additional","affiliation":[{"name":"Shiraz Institute for Cancer Research Shiraz University of Medical Science Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran B.","family":"Lankrani","sequence":"additional","affiliation":[{"name":"Gastroenterohepatology Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Health Policy Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohsen","family":"Dehghani","sequence":"additional","affiliation":[{"name":"Gastroenterohepatology Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholam reza","family":"Pouladfar","sequence":"additional","affiliation":[{"name":"Prof. Alborzi Clinical Microbiology Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093943"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(20000315)48:6<313::AID-JEMT1>3.0.CO;2-Y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.615"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00559.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.10.71"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-012-1241-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381300-8.00005-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03289.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.10.015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.399"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9540-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.28899"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300318110"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2089"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9718-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148514"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12224"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1767"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.38"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737635"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03859.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2010.05.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/176726"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12367","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:22:00Z","timestamp":1694305320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/hel.12367"],"URL":"https:\/\/doi.org\/10.1111\/hel.12367","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,19]]},"article-number":"e12367"}}