{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:40:22Z","timestamp":1792597222519,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although all <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H.\u00a0pylori<\/jats:italic>)\u2010positive patients should receive eradication therapy, the therapy is a challenge for patients allergic to penicillin. There have been a few reports on the efficacy of eradication therapy for such patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the efficacy of vonoprazan or proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>)\u2010based 7\u2010day triple therapy in patients allergic to penicillin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 88 consecutive patients allergic to penicillin who received <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy were retrospectively analyzed. Thirty\u2010one patients had a history of failed eradication therapy. Four 7\u2010day regimens were prescribed during the study period: clarithromycin\u2010metronidazole\u2010<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> (13 patients), clarithromycin\u2010metronidazole\u2010vonoprazan (14 patients), metronidazole\u2010sitafloxacin\u2010<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> (44 patients) and metronidazole\u2010sitafloxacin\u2010vonoprazan (17 patients). A <jats:sup>13<\/jats:sup>C\u2010urea breath test was used for confirmation of eradication, and efficacy of eradication was evaluated by \u201cintention\u2010to\u2010treat\u201d analysis and \u201cper\u2010protocol\u201d analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intention\u2010to\u2010treat and per\u2010protocol eradication rates were 46.2%\/54.6% for patients who received clarithromycin\u2010metronidazole\u2010<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>, 92.9\/92.9% for patients who received clarithromycin\u2010metronidazole\u2010vonoprazan, 100\/100% for patients who received metronidazole\u2010sitafloxacin\u2010<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> and 88.2\/93.8% for patients who received metronidazole\u2010sitafloxacin\u2010vonoprazan. For first eradication, vonoprazan significantly raised the intention\u2010to\u2010treat efficacy of the triple therapy including clarithromycin\u2010metronidazole (vonoprazan: 92.9%, <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>: 46.2%, <jats:italic>P<\/jats:italic>=.0128). A 7\u2010day regimen consisting of metronidazole and sitafloxacin was effective for patients allergic to penicillin with or without past failure of eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For first eradication in patients allergic to penicillin, a 7\u2010day triple therapy consisting of clarithromycin, metronidazole and vonoprazan could be a candidate eradication regimen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12374","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T11:06:57Z","timestamp":1484737617000},"source":"Crossref","is-referenced-by-count":50,"title":["Vonoprazan improves the efficacy of <i>Helicobacter pylori<\/i> eradication therapy with a regimen consisting of clarithromycin and metronidazole in patients allergic to penicillin"],"prefix":"10.1111","volume":"22","author":[{"given":"Shoko","family":"Ono","sequence":"first","affiliation":[{"name":"Division of Endoscopy Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Hakodate Hospital  Hakodate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Mabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Hakodate Hospital  Hakodate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, Vol 61: Schistosomes, Liver Flukes and Helicobacter pylori","author":"International Agency for Research on Cancer","year":"1994"},{"key":"e_1_2_6_3_1","volume-title":"Helicobacter pylori Eradication as a Strategy for Preventing Gastric Cancer","author":"IARC Helicobacter pylori Working 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