{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:36:31Z","timestamp":1790771791348,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["No. 2014R1A1A3052423"],"award-info":[{"award-number":["No. 2014R1A1A3052423"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The role of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) in the development of colorectal neoplasm remains controversial. We examined the association between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and colorectal neoplasm in a large sample of healthy participants who underwent screening colonoscopy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study of 8916 men, who participated in a regular health\u2010screening examination that included an\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010specific immunoglobulin G antibody test and colonoscopy, was conducted to evaluate the association between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      and colorectal neoplasm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariable analyses adjusted for age, body mass index, smoking status, alcohol intake, regular exercise, regular aspirin use, and family history of colorectal cancer showed that the odds ratio (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      ) (95% confidence interval [\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ]) for any adenoma and advanced neoplasm was 1.32 (1.07\u20101.61) and 1.90 (1.05\u20103.56) in participants with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and without\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection, respectively. The association persisted after further adjustment for inflammatory markers or metabolic variables including fasting blood glucose, triglycerides, high\u2010density lipoprotein\u2010cholesterol, and low\u2010density lipoprotein\u2010cholesterol. Regarding the location, a positive association was confined to cases with proximal adenomas and was observed similarly in all the evaluated subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In a large\u2010scale study, carefully controlled for confounding factors, involving asymptomatic participants without a history of colonoscopy,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was significantly associated with the risk of any colorectal adenoma and advanced colorectal neoplasm. Prospective studies are necessary to determine whether\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication can reduce this risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12377","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T03:07:09Z","timestamp":1485400029000},"source":"Crossref","is-referenced-by-count":52,"title":["<i>Helicobacter pylori<\/i>\n                    infection is an independent risk factor of early and advanced colorectal neoplasm"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-9034","authenticated-orcid":false,"given":"Tae Jun","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Health Promotion Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun 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