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This study validated whether CGI<\/jats:styled-content> is more prevalent in H. pylori<\/jats:italic>\u2010infected nonulcer dyspepsia (NUD<\/jats:styled-content>) subjects than in duodenal ulcer (DU<\/jats:styled-content>) controls and whether it is reversible after H. pylori<\/jats:italic> eradication or is correlated with noninvasive biomarkers.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>In this longitudinal cohort study, 573 H. pylori<\/jats:italic>\u2010infected subjects were enrolled, including 349 NUD<\/jats:styled-content> and 224 DU<\/jats:styled-content>. Gastric specimens were provided to assess CGI<\/jats:styled-content>, spasmolyic polypeptide\u2010expressing metaplasia (SPEM<\/jats:styled-content>), and Operative Link on Gastric Intestinal Metaplasia assessment (OLGIM<\/jats:styled-content>). Serum pepsinogen I and II<\/jats:styled-content> levels were assessed using enzyme\u2010linked immunosorbent assay. CGI<\/jats:styled-content> subjected were followed up at least 1\u00a0year after H. pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec>Results<\/jats:title>NUD<\/jats:styled-content> subjects had higher prevalence rates of CGI<\/jats:styled-content> (47.0% vs 29.9%, P<\/jats:italic><.001) and OLGIM<\/jats:styled-content> stages III<\/jats:styled-content>\u2010IV<\/jats:styled-content> (24.1% vs 15.2%, P<\/jats:italic>=.01) than controls. CGI<\/jats:styled-content> was highly prevalent in NUD<\/jats:styled-content> subjects after the age of 40, which was 10 years earlier than atrophic gastritis and intestinal metaplasia. NUD<\/jats:styled-content> subjects with CGI<\/jats:styled-content> had higher risk of SPEM<\/jats:styled-content> (OR<\/jats:styled-content> 2.86, P<\/jats:italic><.001) and lower serum pepsinogen I\/II<\/jats:styled-content> ratios (P<\/jats:italic><.001) than those without CGI<\/jats:styled-content>. Serum pepsinogen I\/II<\/jats:styled-content> ratios <9 could predict CGI<\/jats:styled-content> modestly (AUROC<\/jats:styled-content> 0.69, 95% CI<\/jats:styled-content>: 0.63\u20100.74). CGI<\/jats:styled-content> was regressed after eradication (P<\/jats:italic><.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CGI<\/jats:styled-content> was more prevalent in H. pylori<\/jats:italic>\u2010infected NUD<\/jats:styled-content> subjects than in controls, was correlated with SPEM<\/jats:styled-content>, and may serve as a marker earlier than OLGIM<\/jats:styled-content> to indicate risk of gastric cancer. Moreover, CGI<\/jats:styled-content> could be regressed after eradication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12385","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T05:18:24Z","timestamp":1490246304000},"source":"Crossref","is-referenced-by-count":17,"title":["The corpus\u2010predominant gastritis index can be an early and reversible marker to identify the gastric cancer risk of Helicobacter pylori<\/i>\u2010infected nonulcer dyspepsia"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0954-0647","authenticated-orcid":false,"given":"Hsiu\u2010Chi","family":"Cheng","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ching","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Internal Medicine Tainan Hospital Ministry of Health and Welfare Executive Yuan Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Bai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Pathology Ton Yen General Hospital Hsinchu Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chun","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Lun","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Yu","family":"Kuo","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Chan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bor\u2010Shyang","family":"Sheu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Internal Medicine Tainan Hospital Ministry of Health and Welfare Executive Yuan Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.05.036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc703"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.04.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12185"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_2_8_8_1","first-page":"603","article-title":"A nested case\u2010control study on the association between Helicobacter pylori infection and gastric cancer risk in a cohort of 9775 men in Taiwan","volume":"15","author":"Lin JT","year":"1995","journal-title":"Anticancer Res"},{"key":"e_1_2_8_9_1","first-page":"177","article-title":"Schistosomes, liver fukes and Helicobacter pylori","volume":"61","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 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