{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:06:08Z","timestamp":1788462368655,"version":"build-2803163510"},"reference-count":81,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of <jats:italic>Helicobacter pylori<\/jats:italic> eradication regimens may depend on the country where the studies were performed because of the difference in antibiotic resistance. We aimed to analyze the efficacy of <jats:italic>H.\u00a0pylori<\/jats:italic> eradication regimens in Korea where clarithromycin resistance rate is high.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched for all relevant randomized controlled trials published until November 2016 that investigated the efficacy of <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapies in Korea. A network meta\u2010analysis was performed to calculate the direct and indirect estimates of efficacy among the eradication regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three studies were identified through a systematic review, of which 34 studies, published since 2005, were included in the meta\u2010analysis. Among 21 included regimens, quinolone\u2010containing sequential therapy for 14\u00a0days (<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010Q\u201014) showed the highest eradication rate (91.4% [95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>], 86.9%\u201094.4%] in the intention\u2010to\u2010treat [<jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content>] analysis). The eradication rate of the conventional triple therapy for 7\u00a0days, standard sequential therapy for 10\u00a0days, hybrid therapy for 10\u201014\u00a0days, and concomitant therapy for 10\u201014\u00a0days was 71.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 68.3%\u201073.7%), 76.2% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 72.8%\u201079.3%), 79.4% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 75.5%\u201082.8%), and 78.3% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 75.3%\u201080.9%), respectively, in the <jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content> analysis. In the network meta\u2010analysis, <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010Q\u201014 showed a better comparative efficacy than the conventional triple therapy, standard sequential therapy, hybrid therapy, and concomitant therapy. In addition, tolerability of <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010Q\u201014 was comparable to those regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Korea, <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010Q\u201014 showed the highest efficacy in terms of eradication and a comparable tolerability, compared to the results reported for the conventional triple therapy, standard sequential therapy, hybrid therapy, and concomitant therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12389","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T03:08:49Z","timestamp":1492657729000},"source":"Crossref","is-referenced-by-count":37,"title":["Efficacy of <i>Helicobacter pylori<\/i> eradication therapies in Korea: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"22","author":[{"given":"Yoon Suk","family":"Jung","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-3481","authenticated-orcid":false,"given":"Chan Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunwoo","family":"Nam","sequence":"additional","affiliation":[{"name":"Biostatistical Consulting and Research Lab, Medical Research Coordinating Center Hanyang University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang Lak","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hanyang University Hospital Hanyang University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"299","article-title":"Helicobacter pylori in developing countries. 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