{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:11:36Z","timestamp":1770718296462,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,9,10]],"date-time":"2017-09-10T00:00:00Z","timestamp":1505001600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> is usually acquired in early childhood and the infection persists lifelong without causing symptoms. In a small of cases, the infection leads to gastric or duodenal ulcer disease, or gastric cancer. Why disease occurs in these individuals remains unclear, however the host response is known to play a very important part. Understanding the mechanisms involved in maintaining control over the immune and inflammatory response is therefore extremely important. Vaccines against <jats:italic>H.\u00a0pylori<\/jats:italic> have remained elusive but are desperately needed for the prevention of gastric carcinogenesis. This review focuses on research findings which may prove useful in the development of prognostic tests for gastric cancer development, therapeutic agents to control immunopathology, and effective vaccines.<\/jats:p>","DOI":"10.1111\/hel.12406","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T02:05:15Z","timestamp":1505095515000},"source":"Crossref","is-referenced-by-count":9,"title":["<i>Helicobacter<\/i>: Inflammation, immunology and vaccines"],"prefix":"10.1111","volume":"22","author":[{"given":"Karen","family":"Robinson","sequence":"first","affiliation":[{"name":"Nottingham Digestive Diseases Biomedical Research Centre School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyo","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Biomedical Research Centre School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif Percival","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Copenhagen University Hospital (Rigshospitalet)  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502261"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43052"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.07.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.11.032"},{"key":"e_1_2_6_6_1","article-title":"Lymphotoxin beta receptor signalling executes Helicobacter pylori\u2010driven gastric inflammation in a T4SS\u2010dependent manner","author":"Mejias\u2010Luque R","year":"2016","journal-title":"Gut"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2016-203641"},{"key":"e_1_2_6_8_1","first-page":"227","article-title":"Association between Helicobacter pylori cagA, babA2 virulence factors and gastric mucosal interleukin\u201033 mRNA expression and clinical outcomes in dyspeptic patients","volume":"4","author":"Shahi H","year":"2015","journal-title":"Int J Mol Cell Med"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00071-16"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.158"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00175.2016"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00450-16"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307175"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2016.10"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12587"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12348"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82655"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7823"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2016.02.036"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600137"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.5"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2004.tb03474.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.1.279-285.1999"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.2.1022"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-016-0142-0"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307020"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12367"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000298"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601292"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr15048889"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614958114"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83585"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.60"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-016-2231-2"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167440"},{"key":"e_1_2_6_36_1","first-page":"615","article-title":"Over\u2010expression of microRNA\u2010223 inhibited the proinflammatory responses in Helicobacter pylori\u2010infection macrophages by down\u2010regulating IRAK\u20101","volume":"8","author":"Wang J","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_6_37_1","first-page":"3700","article-title":"MicroRNA\u2010155 in exosomes secreted from Helicobacter pylori infection macrophages immunomodulates inflammatory response","volume":"8","author":"Wang J","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00190-16"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501062"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1MA0316-131R"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12366"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2017.02.007"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MB00772D"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801610010097"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000404"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.38"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.02.021"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11092"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-016-2173-5"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12676"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2016.10.002"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-016-7333-y"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-016-2209-x"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T22:18:20Z","timestamp":1694557100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":52,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/hel.12406"],"URL":"https:\/\/doi.org\/10.1111\/hel.12406","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]},"article-number":"e12406"}}