{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:13:58Z","timestamp":1790633638233,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n In Japan, there have been approximately 50\u00a0000 deaths from gastric cancer annually for over 40\u00a0years with little variation. It has been reported that most gastric cancers in Japan are caused by\n Helicobacter pylori<\/jats:italic>\n infection.\n H.\u00a0pylori<\/jats:italic>\n eradication therapy was approved for patients with chronic gastritis by the Japanese national health insurance scheme in February 2013 for patients with an endoscopic diagnosis of chronic gastritis is positive for\n H.\u00a0pylori<\/jats:italic>\n . We examined the effect on gastric cancer death rate 4\u00a0years after expansion of health insurance coverage.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n We conducted an epidemiological study and analyzed trends in prescription for\n H.\u00a0pylori<\/jats:italic>\n eradication therapy. We used the electronic medical claims database from Hokkaido, Japan to evaluate the impact of expansion of national health insurance coverage for\n H.\u00a0pylori<\/jats:italic>\n eradication therapy on deaths from gastric cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data on deaths from gastric cancer were obtained from the Japanese Ministry of Health, Labour and Welfare and the Cancer Statistics in Japan (2015). Analysis of electronic claims records was performed using the National Database, mainly focusing on Hokkaido. Prescriptions for\n H.\u00a0pylori<\/jats:italic>\n eradication therapy and the number of patients treated for gastric cancer were also extracted from the Hokkaido database.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Approximately 1.5 million prescriptions for\n H.\u00a0pylori<\/jats:italic>\n eradication therapy were written annually. Gastric cancer deaths fell each year: 48\u00a0427 in 2013, 47\u00a0903 in 2014, 46\u00a0659 in 2015, and 45\u00a0509 in 2016, showing a significant decrease after expansion of insurance coverage for\n H.\u00a0pylori<\/jats:italic>\n eradication therapy (\n P<\/jats:italic>\n <.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Prescriptions for\n H.\u00a0pylori<\/jats:italic>\n eradication therapy increased markedly after approval of the gastritis indication by the national health insurance scheme and was associated with a significant decrease in gastric cancer deaths.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.12415","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T15:52:43Z","timestamp":1501775563000},"source":"Crossref","is-referenced-by-count":121,"title":["Effect on\n Helicobacter pylori<\/i>\n eradication therapy against gastric cancer in Japan"],"prefix":"10.1111","volume":"22","author":[{"given":"Momoko","family":"Tsuda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7768-3434","authenticated-orcid":false,"given":"Masahiro","family":"Asaka","sequence":"additional","affiliation":[{"name":"Health Sciences University of Hokkaido Tobetsu\u2010cho Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Kato","sequence":"additional","affiliation":[{"name":"National Hospital Organization Hakodate Hospital Hakodate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumiko","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Health Administration and Policy Tohoku University School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Akino","sequence":"additional","affiliation":[{"name":"Health Sciences University of Hokkaido Tobetsu\u2010cho Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Public Health Aichi Medical University School of Medicine Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingsong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Public Health Aichi Medical University School of Medicine Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.4.626"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2001.00042.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198912073212302"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706183162501"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80013-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27965"},{"key":"e_1_2_7_9_1","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7\u201014 June 1994","volume":"61","author":"IARC","year":"1994","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00799.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00889.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00859.x"},{"key":"e_1_2_7_14_1","unstructured":"IARC Working Group Reports 2013 Volume 8 Helicobacter pylori eradication as a strategy for preventing gastric cancer.http:\/\/www.iarc.fr\/en\/publications\/pdfs-online\/wrk\/wrk8\/Helicobacter_pylori_Eradication.pdf."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn017"},{"key":"e_1_2_7_16_1","unstructured":"Trends in site\u2010specific crude mortality rate 1965\u20132014. Cancer Statistics in Japan\u20102015 Tokyo Japan.2015:39.http:\/\/ganjoho.jp\/data\/reg_stat\/statistics\/brochure\/2015\/cancer_statistics_2015.pdf."},{"key":"e_1_2_7_17_1","unstructured":"Survival rate in the member hospitals of the association of clinical cancer centers (Diagnosed in 2004\u20132007). Cancer Statistics in Japan\u20102015 Tokyo Japan.2015:92\u201095.http:\/\/ganjoho.jp\/data\/reg_stat\/statistics\/brochure\/2015\/cancer_statistics_2015.pdf."},{"key":"e_1_2_7_18_1","first-page":"138","article-title":"Evaluation of H. pylori eradication by electronic recept analysis in Japan","volume":"11","author":"Fujimori K","year":"2015","journal-title":"GI Forefront."},{"key":"e_1_2_7_19_1","unstructured":"NDB Database(Ministry of Health Labour and Welfare website).http:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000139390.html."},{"key":"e_1_2_7_20_1","volume-title":"Cancer Registry and Statistics"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyt163"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0897-8"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:45:14Z","timestamp":1695537914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,3]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/hel.12415"],"URL":"https:\/\/doi.org\/10.1111\/hel.12415","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,3]]},"article-number":"e12415"}}