{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:29:47Z","timestamp":1767835787008,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T00:00:00Z","timestamp":1511654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is some evidence that prior use of macrolide antibiotics is a useful predictor of the likelihood of standard triple therapy failure in <jats:italic>Helicobacter pylori<\/jats:italic> eradication. In this study, we have evaluated whether previous intake of macrolides correlates with failure to eradicate <jats:italic>H.\u00a0pylori<\/jats:italic> using two different first\u2010line clarithromycin\u2010containing regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Retrospective study of 212 patients with <jats:italic>H.\u00a0pylori<\/jats:italic> infection treated with one of two first\u2010line clarithromycin\u2010containing regimens: 108 patients treated with triple therapy for 10\u00a0days and 104 patients treated with concomitant therapy for 10\u00a0days. The intake of macrolides (clarithromycin, azithromycin, and other macrolides) prior to the eradication therapy was obtained from the electronic medical record, which contains information regarding all the medication prescribed to the patients since the year 2004.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred of 212 patients (47.2%) had received at least one treatment with macrolides during the years prior to the eradication therapy. <jats:italic>H.\u00a0pylori<\/jats:italic> eradication rates were significantly lower in patients with previous use compared to patients without previous use of macrolides, both with triple therapy (60.8% vs 92.9%; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.0001) and with concomitant therapy (85.7% vs 98.2%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Previous use of macrolides correlates with a low <jats:italic>H.\u00a0pylori<\/jats:italic> eradication rate with triple and concomitant clarithromycin\u2010containing regimens. In addition, our study shows that in patients without previous use of macrolides, triple therapy achieves per\u2010protocol eradication rates over 90%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12452","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T02:26:50Z","timestamp":1511749610000},"source":"Crossref","is-referenced-by-count":21,"title":["Macrolide use in the previous years is associated with failure to eradicate <i>Helicobacter pylori<\/i> with clarithromycin\u2010containing regimens"],"prefix":"10.1111","volume":"23","author":[{"given":"Pablo","family":"Mu\u00f1oz\u2010G\u00f3mez","sequence":"first","affiliation":[{"name":"Gastroenterology Department Complejo Hospitalario de Toledo  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junior Alexander","family":"Jord\u00e1n\u2010Castro","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital del Bierzo  Ponferrada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Abanades\u2010Tercero","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Complejo Hospitalario de Toledo  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Javier","family":"Blanco\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Complejo Hospitalario de Toledo  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Mar\u00eda","family":"Andr\u00e9s Esteban","sequence":"additional","affiliation":[{"name":"Universidad Jaume I  Castell\u00f3 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6526-4590","authenticated-orcid":false,"given":"Julio","family":"Valle\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Complejo Hospitalario de Toledo  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2013.01.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.03.050"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02922-14"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304820"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13069"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03386.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13497"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00144-10"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2016.12.019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.05.028"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-6-200309160-00008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302254"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.12.001"},{"key":"e_1_2_7_18_1","first-page":"79","article-title":"Helicobacter pylori eradication rates with concomitant quadruple therapy and with optimized triple therapy in Toledo\u2032s health area: randomized clinical trial","volume":"33","author":"Jord\u00e1n\u2010Castro JA","year":"2017","journal-title":"Rev ACAD"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00757.x"},{"issue":"1","key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/hel.12342","article-title":"Treatment of Helicobacter pylori infection 2016","volume":"21","author":"O'Connor A","year":"2016","journal-title":"Helicobacter"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12128"},{"key":"e_1_2_7_22_1","first-page":"234","article-title":"An assessment of the efficacy of first\u2010line Helicobacter pylori\u2010eradication therapy based on clarithromycin susceptibility","volume":"62","author":"Miyaki A","year":"2016","journal-title":"Minerva Gastroenterol Dietol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12231"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.210"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:39:52Z","timestamp":1695965992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,26]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/hel.12452"],"URL":"https:\/\/doi.org\/10.1111\/hel.12452","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,26]]},"article-number":"e12452"}}