{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:04:22Z","timestamp":1792649062000,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU\u2010DK107006"],"award-info":[{"award-number":["KMU\u2010DK107006"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU\u2010TP105G01"],"award-info":[{"award-number":["KMU\u2010TP105G01"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU\u2010TP\u2010105G00"],"award-info":[{"award-number":["KMU\u2010TP\u2010105G00"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H.\u00a0pylori<\/jats:italic>) infection causes elevation of lipid peroxidation product malondialdehyde (MDA) and this association may be due to the bacterium causing reactive oxygen species\u2010mediated damage to DNA in the gastric epithelium. The aim of this study was to investigate the gastric juice MDA levels in relation to <jats:italic>H.\u00a0pylori<\/jats:italic> infection and associated gastric diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gastric juice samples were obtained from 117 patients undergoing endoscopy, and gastric juice MDA levels were determined by high\u2010performance liquid chromatography (HPLC) system. We compared the MDA levels between patients with and without <jats:italic>H.\u00a0pylori<\/jats:italic> infection and assessed the differences of MDA levels between chronic gastritis, gastric intestinal metaplasia, and gastric cancer postsurgical resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Malondialdehyde levels in gastric juice were significantly higher in chronic gastritis patients with <jats:italic>H.\u00a0pylori<\/jats:italic> infection than in those without <jats:italic>H.\u00a0pylori<\/jats:italic> infection (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). In patients without <jats:italic>H.\u00a0pylori<\/jats:italic> infection, patients with gastric intestinal metaplasia and gastric cancer postsurgical resection had significantly higher gastric juice MDA level than patients with chronic gastritis. As a whole, patients with gastric intestinal metaplasia and gastric cancer postsurgical resection also had significantly higher MDA levels in gastric juice as compared to patients with chronic gastritis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). However, the difference of gastric juice MDA levels between gastric intestinal metaplasia and gastric cancer postsurgical resection was not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Malondialdehyde in gastric juice could be used as a potential diagnostic biomarker for <jats:italic>H.\u00a0pylori<\/jats:italic> infection and associated gastric diseases. The gastric juice MDA levels increased proportionally with the severity of gastric diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12460","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T01:02:42Z","timestamp":1515546162000},"source":"Crossref","is-referenced-by-count":23,"title":["Levels of malondialdehyde in the gastric juice: Its association with <i>Helicobacter pylori<\/i> infection and stomach diseases"],"prefix":"10.1111","volume":"23","author":[{"given":"Yao\u2010Kuang","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Municipal Hsiao\u2010Kang Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Chih","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Chen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Shool of Medicine College of Medicine E\u2010Da Hospital I\u2010Shou University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Chieh","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Municipal Ta\u2010Tung Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang\u2010Yao","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie S.W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Jung","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Hsu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3742-0634","authenticated-orcid":false,"given":"Deng\u2010Chyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine 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