{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:07:49Z","timestamp":1767164869072,"version":"build-2238731810"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Although many epidemiologic studies have evaluated the effect of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      eradication on gastric cancer, the effect is still uncertain in general populations. We evaluated whether\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      eradication would affect the incidence of gastric cancer in healthy asymptomatic populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective cohort study in 38\u00a0984 asymptomatic individuals, who underwent health screening examinations more than twice between 2005 and 2016. We investigated the incidence of gastric cancer among 3 groups: those without\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      infection (Hp\u2010negative group), those with\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      eradication (eradication group), and those without\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      eradication (non\u2010eradication group).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cumulative incidence of gastric cancer was 54.5 cases per 100\u00a0000 person\u2010years during a median of 6.4\u00a0years. In a multivariate analysis using the Cox proportional hazard model, the cumulative incidence of gastric cancer in the non\u2010eradication group was significantly higher than those in the Hp\u2010negative (hazard ratio [\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      ] 4.12,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .001) and eradication groups (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      2.73,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .001). However, the cumulative incidence of gastric cancer was not significantly different between the eradication and Hp\u2010negative groups. Other risk factors for gastric cancer occurrence were age, smoking, family history of gastric cancer, and gastric atrophy. The standardized incidence ratios of the age groups above 40 and below 70 in the eradication group were all significantly decreased.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      eradication reduced the cumulative incidence of gastric cancer in healthy asymptomatic population, and the effect of\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      eradication on the prevention of gastric cancer was observed in all ages.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12464","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T06:49:16Z","timestamp":1516258156000},"source":"Crossref","is-referenced-by-count":43,"title":["The effect of eradication of\n                    <i>Helicobacter pylori<\/i>\n                    on gastric cancer prevention in healthy asymptomatic populations"],"prefix":"10.1111","volume":"23","author":[{"given":"Suh Eun","family":"Bae","sequence":"first","affiliation":[{"name":"Health Screening and Promotion Center University of Ulsan Collage of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-4109","authenticated-orcid":false,"given":"Kee Don","family":"Choi","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology University of Ulsan Collage of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaewon","family":"Choe","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center University of Ulsan Collage of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon Ok","family":"Kim","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Kyong","family":"Na","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology University of Ulsan Collage of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center University of Ulsan Collage of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology University of Ulsan Collage of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee 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