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However, phenotypic methods have some limitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the feasibility of genotypic detection methods compared with phenotypic detection methods using samples taken from <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature searches were conducted in the following databases (from January 2000 to November 2016): PubMed, Embase, the Cochrane Library, and Web of Science. A meta\u2010analysis and systematic review was performed for studies that compared genotypic methods with phenotypic methods for the detection of <jats:italic>H.\u00a0pylori<\/jats:italic> antibiotic susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This meta\u2010analysis showed that the pooled sensitivity, specificity, and diagnostic odds ratio (<jats:styled-content style=\"fixed-case\">DOR<\/jats:styled-content>) for the A2142G\/C and\/or A2143G combination for the detection of clarithromycin resistance in the strain samples were 0.97 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.94\u20100.99), 1.00 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.99\u20101.00), and 13\u00a0742 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1708\u2010110\u00a0554), respectively. The pooled sensitivity, specificity, and <jats:styled-content style=\"fixed-case\">DOR<\/jats:styled-content> for the A2142G\/C and\/or A2143G combination for the detection of clarithromycin resistance in biopsy samples were 0.96 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.90\u20100.99), 0.96 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.91\u20100.99), and 722 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 117\u20104443), respectively. The summarized sensitivity, specificity, and <jats:styled-content style=\"fixed-case\">DOR<\/jats:styled-content> value for the ability of the genotypic methods to detect quinolone resistance in biopsy specimens were 0.97 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.87\u20100.99), 0.99 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.92\u20101.00), and 6042 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 486\u201075\u00a0143), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The genotypic detection methods were reliable for the diagnosis of clarithromycin and quinolone resistance in the strain and biopsy specimens. The A2142G\/C and\/or A2143G combination had the best sensitivity and specificity for the detection of clarithromycin resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12467","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T11:15:13Z","timestamp":1517915713000},"source":"Crossref","is-referenced-by-count":45,"title":["A systematic review and meta\u2010analysis of genotypic methods for detecting antibiotic resistance in <i>Helicobacter pylori<\/i>"],"prefix":"10.1111","volume":"23","author":[{"given":"You\u2010hua","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical College Nanchang University  Nanchang Jiangxi Province 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