{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:07:50Z","timestamp":1787497670828,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460115"],"award-info":[{"award-number":["81460115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004637","name":"Nanchang University","doi-asserted-by":"publisher","award":["No.cx2016315"],"award-info":[{"award-number":["No.cx2016315"]}],"id":[{"id":"10.13039\/501100004637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antibiotic resistance is a major cause of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    (\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    ) treatment failures. Because the resistance rate of\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    to furazolidone is low, we aimed to assess the efficacy and safety of furazolidone. We searched the PubMed, Web of Science, Cochrane Library, and Embase databases and included randomized controlled trials (RCT) that either compared furazolidone to other antibiotics or changed the administered dose of furazolidone. A total of 18 articles were included in the meta\u2010analysis. According to the intention\u2010to\u2010treat (ITT) analysis, the total eradication rates of furazolidone\u2010containing therapy were superior to those of other antibiotic\u2010containing therapies (relative risk [RR] 1.07, 95% confidence interval [CI] 1.01\u20101.14) (13 RCTs). Specifically, the eradication rates of furazolidone\u2010containing therapy were better than those for metronidazole\u2010containing therapy (RR 1.10, 95% CI: 1.01\u20101.21 for ITT). The eradication rate of furazolidone\u2010containing bismuth\u2010containing quadruple therapy was 92.9% (95% CI: 90.7%\u201095.1%) (PP). In addition, a higher daily dose of furazolidone increased the eradication rate (RR 1.17, 95% CI: 1.05\u20101.31). And the incidence of some adverse effects, such as fever and anorexia, was higher in the furazolidone group than in the control group, the overall incidences of total side effects and severe side effects showed no significant differences between the groups. Furazolidone\u2010containing treatments could achieve satisfactory eradication rates and did not increase the incidence of total or severe adverse effects, but the incidence of milder side effects, such as fever and anorexia, should be considered when prescribing furazolidone\u2010containing treatments to patients.\n                  <\/jats:p>","DOI":"10.1111\/hel.12468","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T05:44:30Z","timestamp":1519623870000},"source":"Crossref","is-referenced-by-count":69,"title":["Furazolidone treatment for\n                    <i>Helicobacter Pylori<\/i>\n                    infection: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"given":"Liya","family":"Zhuge","sequence":"first","affiliation":[{"name":"Department of Gastroenterology the First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru\u2010Lin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"},{"name":"Department of Biochemistry and Molecular Biology Jiangxi Academy of Medical Science  Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"},{"name":"The Medical College of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5290-5579","authenticated-orcid":false,"given":"Yong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-005-0204-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12159"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12034"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00518.x"},{"key":"e_1_2_7_7_1","first-page":"525","article-title":"Prevalence of helicobacter pylori resistance to antibiotics and its influence of the treatment outcome in china: a multicenter clinical study","volume":"12","author":"Cheng H","year":"2007","journal-title":"Chin J 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Chinese Journal of New","volume":"10","author":"Jiang CG","year":"2010","journal-title":"Drugs"},{"key":"e_1_2_7_28_1","first-page":"253","article-title":"Comparison of acid and Helicobacter pylori in ulcerogenesis of duodenal ulcer disease","volume":"73","author":"Hu FL","year":"1993","journal-title":"Zhong Hua Yi Xue Za Zhi"},{"key":"e_1_2_7_29_1","first-page":"503","article-title":"The efficacy of furazolidone and metronidazole in the treatment of chronic gastritis associated with Helicobacter (campylobacter) pylori \u2010 a randomized double\u2010blind placebo\u2010controlled clinical trial","volume":"37","author":"Xiao SD","year":"1990","journal-title":"Hepato\u2010Gastroenterol"},{"key":"e_1_2_7_30_1","first-page":"480","article-title":"Therapeutic effect of clarithromycin\u2010based triple therapy for Helicobacter pylori eradication","volume":"17","author":"Zhang Q","year":"2012","journal-title":"Chin J 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