{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:34:23Z","timestamp":1753878863963,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>Hp<\/jats:italic>) are the most common agents causing gastric mucosal injury worldwide. Foveolar hyperplasia is a key component of the stomach's reaction to injury. This study examines histopathologic characteristics associated with <jats:italic>Helicobacter pylori<\/jats:italic> and with non\u2010 <jats:italic>Helicobacter pylori<\/jats:italic>\u2010associated gastropathy in children and adolescents, and compares the prevalence of foveolar hyperplasia among these disease subgroups and normal control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010one gastric antral and corpus biopsies from subjects 2\u201019\u00a0years of age were studied. Twenty\u2010two subjects with <jats:italic>Helicobacter pylori<\/jats:italic> gastritis were compared to 23 with non\u2010<jats:italic>Helicobacter pylori<\/jats:italic> gastropathy and to 36 controls (normal biopsies). Foveolar length, full mucosal thickness, and the foveolar length: full mucosal thickness ratio were derived by a morphometric technique previously developed to analyze adult gastric tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, <jats:italic>Helicobacter pylori<\/jats:italic> gastritis demonstrated significant increases in antral foveolar length (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.0001), full mucosal thickness (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>.0001), as well as corpus foveolar length (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>.05) and corpus full mucosal thickness (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05). Non\u2010<jats:italic>Helicobacter pylori<\/jats:italic>\u2010associated gastropathy also was characterized by increased antral foveolar length (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.0001) and full mucosal thickness (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) but corresponding corpus measurements did not differ from controls. Antral foveolar length in non\u2010<jats:italic>Helicobacter pylori<\/jats:italic> gastropathy was increased, when compared to <jats:italic>Helicobacter pylori<\/jats:italic> gastritis (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>.05), while corpus values were not. The non\u2010<jats:italic>Helicobacter pylori<\/jats:italic> gastropathy group demonstrated increased antral foveolar length: full mucosal thickness ratios, compared with <jats:italic>Helicobacter pylori<\/jats:italic> gastritis (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) and with normal controls (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>An objective, quantitative approach to measuring foveolar hyperplasia in adults was successfully applied to pediatric biopsies and yielded a richer characterization of gastric pathology in children. Foveolar hyperplasia appears to be a generalized phenomenon in the presence of pediatric <jats:italic>Helicobacter pylori<\/jats:italic> gastritis but is limited to the antrum in non\u2010<jats:italic>Helicobacter pylori<\/jats:italic> gastropathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12487","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T06:55:53Z","timestamp":1524725753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pediatric <i>Helicobacter pylori<\/i> gastropathy demonstrates a unique pattern of gastric foveolar hyperplasia"],"prefix":"10.1111","volume":"23","author":[{"given":"Sadaf","family":"Saghier","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Gastroenterology, Hepatology and Nutrition State University of New York Downstate Medical Center  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0871-8506","authenticated-orcid":false,"given":"Steven M.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Gastroenterology, Hepatology and Nutrition State University of New York Downstate Medical Center  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital at Downstate State University of New York Downstate Medical Center  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raavi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital at Downstate State University of New York Downstate Medical Center  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6478-9755","authenticated-orcid":false,"given":"Amin","family":"Heidarian","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital at Downstate State University of New York Downstate Medical Center  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon S.","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Gastroenterology, Hepatology and Nutrition State University of New York Downstate Medical Center  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"524","volume-title":"Histology: A Text and Atlas: With Correlated Cell and Molecular Biology","author":"Ross MH","year":"2006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64324-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2006.04.001"},{"key":"e_1_2_6_5_1","first-page":"1161","article-title":"Classification and grading of gastritis. 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