{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:57:39Z","timestamp":1789498659953,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the effect of <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H.\u00a0pylori<\/jats:italic>) eradication on dyspepsia symptom scores in children with functional dyspepsia (FD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One hundred and fifty functional dyspeptic children (ages 8\u201018\u00a0years, mean: 13.3\u00a0\u00b1\u00a02.84\u00a0years; 30% male) were enrolled to this prospective study. Upper gastrointestinal endoscopy was performed on all patients, and the samples from the gastric antrum and corpus were obtained for the existence of <jats:italic>H.\u00a0pylori<\/jats:italic>. <jats:sup>13<\/jats:sup>Carbon\u2010urea breath test was performed to evaluate the eradication therapy's efficacy. The symptoms were assessed at first visit and at the 8th week and 16th week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine (33%) children were in the <jats:italic>H.\u00a0pylori\u2010<\/jats:italic>positive group, and 101 (67%) children were in the <jats:italic>H.\u00a0pylori\u2010<\/jats:italic>negative group. Dyspepsia symptom scores improved at 8th week in both groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). <jats:italic>Helicobacter pylori<\/jats:italic> was eradicated in 30 patients (61%), while in the <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010eradicated group, all dyspepsia symptoms' scores decreased, and in the <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010uneradicated group, only three symptoms' scores decreased. Symptom scores were lower in <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010eradicated group than <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010uneradicated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the tests used for the diagnosis of <jats:italic>H.\u00a0pylori<\/jats:italic> in functional dyspeptic patients increased the cost of health care, the dyspepsia symptom scores decreased with the eradication therapy in a high prevalence community. The findings may differ in low prevalence communities where the diagnostic tests for <jats:italic>H.\u00a0pylori<\/jats:italic> infection are not recommended in children in the absence of alarm signs or symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12497","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T11:40:27Z","timestamp":1528285227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The effect of <i>Helicobacter pylori<\/i> eradication on functional dyspepsia in Turkish children"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4550-0717","authenticated-orcid":false,"given":"Aysel","family":"\u00dcnl\u00fcsoy Aksu","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Gazi University Faculty of Medicine  Ankara 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