{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:57:05Z","timestamp":1773428225061,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>All\u2010cause death rates and gastric cancer\u2010specific death rates in gastric cancer patients who received successful <jats:italic>H.\u00a0pylori<\/jats:italic> eradication treatment was tracked and compared to rates in patients who did not receive successful eradication therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 160 gastric cancer patients were followed\u2010up for up to 11.7\u00a0years (mean 3.5\u00a0years). Among them, 53 gastric cancer patients received successful <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy prior to gastric cancer diagnosis. During the follow\u2010up period, 11 all\u2010cause deaths occurred. In the successful eradication group, the proportion of patients with cancer stage I was higher. The proportions of patients who received curative endoscopic therapy and endoscopic examination in the 2\u00a0years prior to gastric cancer diagnosis were also higher in the successful eradication group. Kaplan\u2013Meier analysis of all\u2010cause death and gastric cancer\u2010specific death revealed a lower death rate in patients in the successful eradication group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0139, and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0396, respectively, log\u2010rank test). The multivariate analysis showed that endoscopy within 2\u00a0years before cancer diagnosis is associated with stage I cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Possible early discovery of gastric cancer after <jats:italic>H.\u00a0pylori<\/jats:italic> eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12503","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T14:45:39Z","timestamp":1529505939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Early detection of gastric cancer after <i>Helicobacter pylori<\/i> eradication due to endoscopic surveillance"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-6023","authenticated-orcid":false,"given":"Kosuke","family":"Sakitani","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"},{"name":"The Institute for Adult Diseases Asahi Life Foundation  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"},{"name":"Department of Gastroenterology Tokyo Medical Center National Hospital Organization  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Arita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuntaro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"},{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"},{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Ohki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"},{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroharu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"},{"name":"Department of Gastrointestinal Surgery Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Isomura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"},{"name":"Department of Gastroenterology Kanto Central Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"},{"name":"Department of Colorectal Surgery Japanese Red Cross Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenobu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pathology PCL Japan  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Saito","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Fujisaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohisa","family":"Yahagi","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-6079","authenticated-orcid":false,"given":"Osamu","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyoshima Endoscopy Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06767.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12946"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30354-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1274"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl17095"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.36"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0377-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.16-43"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616642341"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5211-4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i37.10553"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.03.791"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0479-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_2_8_19_1","first-page":"963","article-title":"Distribution of inflammation and atrophy in the stomach of Helicobacter pylori\u2010positive and \u2010negative patients with chronic gastritis","volume":"91","author":"Satoh K","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/156719"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00478.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.335"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.055400"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02459.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1109"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23278"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i11.1671"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30111"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5758"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334684"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0504-9"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291491"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T16:29:19Z","timestamp":1694968159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,20]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/hel.12503"],"URL":"https:\/\/doi.org\/10.1111\/hel.12503","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,20]]},"assertion":[{"value":"2018-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12503"}}