{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:59:01Z","timestamp":1790384341656,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>Gastric cancer (GC<\/jats:styled-content>) is still the third leading cause of cancer death in both sexes worldwide. Helicobacter pylori<\/jats:italic> infection is the most important risk factor for GC<\/jats:styled-content> and, in spite of the consistent trend of a decreasing incidence, in 2015 approximately 4.4\u00a0billion individuals\u2014more than half the world's population\u2014were infected with H.\u00a0pylori<\/jats:italic>. The birth cohort pattern of decreased H.\u00a0pylori<\/jats:italic> infection reported in a systematic review contributes to explain the declining GC<\/jats:styled-content> mortality in Japan. Current trends in estimated annual percentage change of GC<\/jats:styled-content> incidence foreshadow expected reversals in both falling incidence and male predominance among US<\/jats:styled-content> non\u2010Hispanic whites. Combining serum pepsinogen 1 and H.\u00a0pylori<\/jats:italic> serology was shown to be useful for GC<\/jats:styled-content> risk stratification in a Finnish population. Gastritis staging by operative link on gastritis assessment was confirmed to be reliable in predicting GC<\/jats:styled-content> risk in a large prospective study. In a randomized trial from South Korea, H.\u00a0pylori<\/jats:italic> eradication therapy significantly reduced the rates of metachronous GC<\/jats:styled-content> in patients who received curative endoscopic resection for early GC<\/jats:styled-content>. A study based on a territory\u2010wide health care database of the Hong Kong Hospital Authority showed that aspirin use is associated with a reduced GC<\/jats:styled-content> risk. Another study based on the same database showed that proton pump inhibitors increase GC<\/jats:styled-content> risk, but methodological biases have most likely acted as confounders. Confirmatory data on the role of endoscopic submucosal dissection in patients with early GC<\/jats:styled-content> have been published. The phase III FLOT<\/jats:styled-content>4 trial has shown that the FLOT<\/jats:styled-content> triplet regimen (docetaxel, oxaliplatin, leucovorin, and 5\u2010fluorouracil) improves the outcome of patients with GC<\/jats:styled-content> and locoregional disease as compared to the ECF<\/jats:styled-content> triplet (epirubicin, cisplatin, and 5\u2010fluorouracil). In the phase III ATTRACTION<\/jats:styled-content>\u20102 trial, nivolumab was shown to be an effective treatment option with a relative safe profile for heavily pretreated patients with advanced GC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hel.12518","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T05:25:17Z","timestamp":1536643517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Gastric cancer: epidemiology, prevention, and therapy"],"prefix":"10.1111","volume":"23","author":[{"given":"Marino","family":"Venerito","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University Hospital Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Vasapolli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University Hospital Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Rokkas","sequence":"additional","affiliation":[{"name":"Gastroenterology Clinic Henry Dunant Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Malfertheiner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University Hospital Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15490-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx262"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14082"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.10.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14471"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314600"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708423"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1800147"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx267"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.117"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314605"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315698"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl17414"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4378945"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617722901"},{"key":"e_1_2_7_18_1","first-page":"1069","article-title":"Neoadjuvant treatment with cisplatin and S\u20101 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: two case reports and review of the literature","volume":"7","author":"Franck C","year":"2017","journal-title":"Mol Clin Oncol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.2130"},{"issue":"15","key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1200\/JCO.2017.35.15_suppl.4004","article-title":"Perioperative chemotherapy with docetaxel, oxaliplatin, and fluorouracil\/leucovorin (FLOT) versus epirubicin, cisplatin, and fluorouracil or capecitabine (ECF\/ECX) for resectable gastric or gastroesophageal junction (GEJ) adenocarcinoma (FLOT4\u2010AIO): a multicenter, randomized phase 3 trial","volume":"35","author":"Al\u2010Batran SE","year":"2017","journal-title":"J Clin 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