{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:58:38Z","timestamp":1790506718078,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The review of the most important recent publications concerning the relation of <jats:italic>Helicobacter pylori<\/jats:italic> with peptic ulcer disease (<jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>), noninvestigated and functional dyspepsia, and gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>) is presented. <jats:italic>H.\u00a0pylori<\/jats:italic> remains the main etiopathogenetic factor in complicated and uncomplicated <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>. Nevertheless, the role of nonsteroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) and aspirin is increasing. The novel data did not confirm that <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content> caused by <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s and aspirin is less symptomatic. The role of glucocorticoids, immunosuppressants, and antidepressants seems to be of some importance. Although the involvement of <jats:italic>H.\u00a0pylori<\/jats:italic> in functional dyspepsia is controversial, several data support the importance of <jats:italic>H.\u00a0pylori\u2010<\/jats:italic>induced gastritis in the pathogenesis of dyspeptic symptoms. Recent interventional studies have reported that <jats:italic>H.\u00a0pylori<\/jats:italic> eradication improves dyspepsia mainly in areas with a high prevalence of this bacterium. Novel data regarding the relation of gastrointestinal peptides, ghrelin and obestatin, with <jats:italic>H.\u00a0pylori<\/jats:italic> infection are also presented. Intriguing findings support the involvement of the gastric microbiota in the causation of chronic functional dyspepsia. Finally, some data concerning negative, positive, or neutral associations of <jats:italic>H.\u00a0pylori<\/jats:italic> with gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>) were published. In this context, today there is no evidence indicating that <jats:italic>H.\u00a0pylori<\/jats:italic> eradication could worsen the symptoms or the course of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hel.12522","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T05:25:17Z","timestamp":1536643517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["<i>Helicobacter pylori<\/i> and nonmalignant upper gastrointestinal diseases"],"prefix":"10.1111","volume":"23","author":[{"given":"Laimas","family":"Jonaitis","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Lithuanian University of Health Sciences  Kaunas 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