{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:35:00Z","timestamp":1792089300975,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds and Aims<\/jats:title><jats:p>Constipation is one of the most common gastrointestinal functional disorders. Recently, the gut microbiota has been implicated in the development of constipation. <jats:italic>Helicobacter pylori<\/jats:italic> infection is considered to be a possible factor influencing the gut microbiota profile. Here, we investigated the effect of <jats:italic>H.\u00a0pylori <\/jats:italic>eradication therapy on symptoms of chronic constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 166 <jats:italic>H pylori<\/jats:italic>\u2010positive patients who underwent eradication therapy after endoscopy. We evaluated the severity of symptoms of chronic constipation before eradication therapy and 2\u00a0months post\u2010therapy using two questionnaires, the Gastrointestinal Symptom Rating Scale (GSRS) and the Izumo scale. In addition, we evaluated association with constipation and <jats:italic>H.\u00a0pylori<\/jats:italic> infection in patients with constipation\u2010related symptoms in not only all patients, but also patients with the constipation\u2010related symptoms in relation to eradication outcome, the severity of constipation\u2010related symptoms, and the severity of endoscopic gastric mucosal atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean GSRS scores were 5.10\u00a0\u00b1\u00a02.67 in all patients and 6.15\u00a0\u00b1\u00a02.91 in constipation patients which were significantly lower than that before eradication (5.78\u00a0\u00b1\u00a03.27, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 and 8.19\u00a0\u00b1\u00a03.09, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01, respectively). Constipation\u2010related scores of the GSRS questionnaire in the successful eradication group were significantly improved after eradication from 5.63\u00a0\u00b1\u00a03.06 in all patients and 8.00\u00a0\u00b1\u00a02.85 in constipation patients to 5.11\u00a0\u00b1\u00a02.71 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and 6.16\u00a0\u00b1\u00a02.96 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), while scores in the failed eradication group before and after eradication were similar. Constipation\u2010related scores in patients with mild gastric atrophy (Kimura\u2010Takemoto classification, C\u2010I to O\u2010I) were significantly decreased after eradication, but were not decreased in patients with severe atrophy (O\u2010II and O\u2010III).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Successful eradication therapy for <jats:italic>H.\u00a0pylori<\/jats:italic> infection may confer additional benefits in <jats:italic>H.\u00a0pylori\u2010<\/jats:italic>positive patients with symptoms of chronic constipation, especially in patients with mild gastric atrophy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12543","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T06:54:40Z","timestamp":1539672880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Successful <i>Helicobacter pylori<\/i> eradication therapy improves symptoms of chronic constipation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-0584","authenticated-orcid":false,"given":"Masaki","family":"Murata","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shiga University of Medical Science Hospital Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-7392","authenticated-orcid":false,"given":"Mitsushige","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Division of Digestive Endoscopy Shiga University of Medical Science Hospital Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-9771","authenticated-orcid":false,"given":"Taketo","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shiga University of Medical Science Hospital Otsu Shiga 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