{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:01:16Z","timestamp":1787065276631,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["CMU107\u2010CR\u201002"],"award-info":[{"award-number":["CMU107\u2010CR\u201002"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["CMRC\u2010CHM\u20105"],"award-info":[{"award-number":["CMRC\u2010CHM\u20105"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 98\u20102320\u2010B\u2010039 \u2010012 \u2010MY3"],"award-info":[{"award-number":["NSC 98\u20102320\u2010B\u2010039 \u2010012 \u2010MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>\n \n Helicobacter pylori<\/jats:italic>\n (\n H.\u00a0pylori<\/jats:italic>\n ) infection is associated with an inflammatory response in the gastric mucosa, leading to chronic gastritis, peptic ulcers, and gastric cancer. Increased T\u2010cell infiltration is found at sites of\n H.\u00a0pylori<\/jats:italic>\n infection. The CCR6\n +<\/jats:sup>\n subset of CD4\n +<\/jats:sup>\n regulatory T cells (Tregs), a newly characterized subset of Tregs, has been reported to contribute to local immune inhibition. However, whether CCR6\n +<\/jats:sup>\n Tregs are present in\n H.\u00a0pylori<\/jats:italic>\n gastritis, and what their relationship is to disease prognosis, remains to be elucidated. In this study, gastric infiltrating lymphocytes were isolated from endoscopic biopsy specimens of\n H.\u00a0pylori<\/jats:italic>\n gastritis patients and analyzed. We found that in gastric infiltrating lymphocytes, CCR6\n +\u00a0<\/jats:sup>\n CD4\n +\u00a0<\/jats:sup>\n CD25\n high<\/jats:sup>\n Tregs, which express high levels of CD45RO, are positively associated with more severe inflammation in gastric mucosa during\n H.\u00a0pylori<\/jats:italic>\n infection. Furthermore, the frequency of CCR6\n +<\/jats:sup>\n Tregs in gastric infiltrating lymphocytes, but not CCR6\n \u2212<\/jats:sup>\n Tregs, is significantly increased in inflamed gastric tissues, which is inversely correlated with significantly lower expression of IFN\u2010\u03b3\n +\u00a0<\/jats:sup>\n CD8\n +<\/jats:sup>\n T cells. We also found that the frequency of CCR6\n +<\/jats:sup>\n Tregs is positively correlated with the frequency of CD4\n +\u00a0<\/jats:sup>\n IFN\u2010\u03b3\n +<\/jats:sup>\n T cells. In addition, the frequency of CCR6\n +<\/jats:sup>\n Tregs, but not that of CCR6\n \u2212<\/jats:sup>\n Tregs, is significantly correlated with increased inflammation in\n H.\u00a0pylori<\/jats:italic>\n gastritis. This study demonstrates that immunosuppression in\n H.\u00a0pylori<\/jats:italic>\n gastritis might be related to the activity of CCR6\n +<\/jats:sup>\n Tregs, which could influence disease prognosis.\n <\/jats:p>","DOI":"10.1111\/hel.12550","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T08:34:41Z","timestamp":1541752481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Recruitment of CCR6\n +\u00a0<\/sup>\n Foxp3\n +<\/sup>\n regulatory gastric infiltrating lymphocytes in\n Helicobacter pylori<\/i>\n gastritis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4205-4686","authenticated-orcid":false,"given":"Yi\u2010Ying","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan"},{"name":"Chinese Medicine Research Center China Medical University Taichung Taiwan"},{"name":"Research Center for Chinese Herbal Medicine China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Tung","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Lotung Poh\u2010Ai Hospital I\u2010Lan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Tsay","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Department of Internal Medicine China Medical University Hospital Taichung Taiwan"},{"name":"Department of Internal Medicine, School of Medicine, China Medical University Hospital China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Ta","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, China Medical University Hospital China Medical University Taichung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Ming","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Nursing Hungkuang University Taichung Taiwan"},{"name":"Division of Allergy, Immunology & Rheumatology Changhua Christian Hospital Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Chen","family":"Shieh","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Nursing Hungkuang University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology Chung Shan Medical University Taichung 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