{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T01:25:00Z","timestamp":1766625900937,"version":"3.41.2"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005385","name":"Council for Higher Education-Israel","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005385","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> causes peptic ulcer disease; however, conflicting evidence exists regarding its role in extragastric conditions. We aimed to examine associations of <jats:italic>H\u00a0pylori<\/jats:italic> infection and peptic ulcer disease with stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was undertaken using data of 147\u00a0936 individuals aged 25\u201095\u00a0years who underwent the urea breath test during 2002\u20102012, based on the computerized database of the second largest health maintenance organization in Israel. Logistic regression models were fitted to control for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1397 (0.9%) patients had stroke and 76\u00a0965 (52.0%) had a <jats:italic>H\u00a0pylori<\/jats:italic> positive test. The likelihood of prevalent stroke increased in relation to <jats:italic>H\u00a0pylori<\/jats:italic> infection: adjusted odds ratio (aOR) 1.16 (95% confidence intervals [CI]: 1.04\u20101.29), gastric ulcer: aOR 1.50 (95% CI: 1.18\u20101.91), and duodenal ulcer: aOR 1.25 (95% CI: 1.07\u20101.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results support the premise that stroke may be associated with a history of <jats:italic>H\u00a0pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12553","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T23:45:42Z","timestamp":1542325542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<i>Helicobacter pylori<\/i> infection and prevalence of 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