{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:55:08Z","timestamp":1772798108392,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23590821"],"award-info":[{"award-number":["23590821"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previously, we conducted an epidemiological study screening for <jats:italic>Helicobacter pylori<\/jats:italic> antibody positivity among Japanese junior high school students. In this study, we updated the epidemiological data and assessed the clinical features of <jats:italic>H\u00a0pylori<\/jats:italic> antibody\u2010positive junior high school students.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We assessed <jats:italic>H\u00a0pylori<\/jats:italic> antibody\u2010positive subjects who were identified between 2012 and 2015 at four junior high schools in Nagano Prefecture, Japan. <jats:italic>H\u00a0pylori<\/jats:italic> infection was confirmed by urea breath test (UBT) or endoscopic examination. Endoscopy was performed after obtaining consent from the subject and their guardians. Eradication therapy consisted of triple therapy with proton pump inhibitor (PPI), amoxicillin (AMPC), and clarithromycin (CAM) or metronidazole (MNZ) for seven days. Eradication of <jats:italic>H\u00a0pylori<\/jats:italic> was confirmed by UBT. We reviewed subjects\u2019 characteristics, endoscopic findings, histological findings, eradication regimes, outcomes, and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of <jats:italic>H\u00a0pylori <\/jats:italic>antibody positivity was 3.2% (42\/1298). We assessed thirteen <jats:italic>H\u00a0pylori<\/jats:italic> antibody\u2010positive subjects. Eight subjects had a family history of <jats:italic>H\u00a0pylori<\/jats:italic> infection. Six subjects had abdominal pain, and two subjects had iron deficiency anemia (IDA). Twelve subjects underwent endoscopy; one subject had duodenal ulcer, eleven subjects had antral nodular gastritis, and six subjects showed grade 2 closed type atrophic border according to the Kimura\u2010Takemoto classification. All subjects received eradication therapy; CAM was used in five subjects with CAM susceptibility as well as in three subjects with unknown information on CAM susceptibility, and MNZ was used in five subjects with CAM resistance. Eradication was successful in twelve subjects (one unconfirmed). There were three mild adverse effects (abdominal pain or diarrhea).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> test for junior high school students represents an opportunity to diagnose the peptic ulcer, iron deficiency anemia, and gastric atrophy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12559","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T01:44:02Z","timestamp":1543974242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical features of <i>Helicobacter pylori<\/i> antibody\u2010positive junior high school students in Nagano Prefecture, Japan"],"prefix":"10.1111","volume":"24","author":[{"given":"Hitoshi","family":"Honma","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine Nagano 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