{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:37:01Z","timestamp":1788863821935,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500504"],"award-info":[{"award-number":["81500504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The high prevalence of <jats:italic>Helicobacter pylori (H\u00a0pylori) <\/jats:italic>infection in China results in a substantial public health burden. Medical experts have not agreed on the best solution of population intervention for this problem. We presented a health economic evaluation of a population\u2010based <jats:italic>H\u00a0pylori <\/jats:italic>screen\u2010and\u2010treat strategy for preventing gastric cancer, peptic ulcer disease (PUD), and nonulcer dyspepsia (NUD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Decision trees and Markov models were developed to evaluate the cost\u2010effectiveness of <jats:italic>H\u00a0pylori<\/jats:italic> screening followed by eradication treatment in asymptomatic Chinese. The modeled screen\u2010and\u2010treat strategy reduced the risk of gastric cancer, PUD, and NUD. The main outcomes were the costs, effectiveness, and the incremental cost\u2010effectiveness ratio. Uncertainty was explored by one\u2010way and probabilistic sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For preventing gastric cancer, PUD, and NUD together in a cohort of 10 million asymptomatic Chinese at the age of 20\u00a0years, the <jats:italic>H\u00a0pylori <\/jats:italic>screen\u2010and\u2010treat strategy saved 288.1 million dollars, 28\u00a0989\u00a0life years, and 111\u00a0663\u00a0quality\u2010adjusted life years, and prevented 11\u00a0611 gastric cancers, 5422 deaths from gastric cancer, and 1854 deaths from PUD during life expectancy. Uncertainty of screening age from 20 to 60 did not affect the superiority of the screen\u2010and\u2010treat strategy over the no\u2010screen strategy. The one\u2010way and probabilistic sensitivity analyses confirmed the robustness of our study's results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with the no\u2010screen strategy, population\u2010based screen\u2010and\u2010treat strategy for <jats:italic>H\u00a0pylori<\/jats:italic> infection proved cheaper and more effective for preventing gastric cancer, PUD, and NUD in Chinese asymptomatic general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12563","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T05:02:20Z","timestamp":1548306140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Cost\u2010effectiveness analysis of screen\u2010and\u2010treat strategy in asymptomatic Chinese for preventing <i>Helicobacter pylori\u2010<\/i>associated diseases"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1354-3509","authenticated-orcid":false,"given":"Qi","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology &amp; 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